지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives: To determine the baseline serum concentrations of estradiol and estrone in postmenopausal Korean women and the serum concentrations of estradiol and estrone after 4 and 16 weeks of treatment using 1 mg of estradiol and 2 mg of drospirenone.
Methods: This was a multicenter study. Thirty-six subjects were screened. Serum estradiol, estrone and drospirenone levels were determined by gas chromatography-mass spectrometry and radioimmunoassay.
Results: The mean estradiol concentration was 8.37 ± 12.1 pg/mL at baseline and increased to 53.7 ± 52.1 and 41.4 ± 26.1 pg/mL after 4 and 16 weeks of treatment, respectively. The mean estrone concentrations were 28.7 ± 26.8, 266.1 ± 182.9, and 256.1 ± 179.1 pg/mL at baseline, and after 4 and 16 weeks of treatment, respectively. When women were stratified according to the basal estradiol level, the level after 4 weeks of treatment was significantly higher in the women with a detectable level (≥ 5 pg/mL) than in women with an undetectable level (＜ 5 pg/mL; 65.2 ± 21.5 vs. 37.4 ± 25.8 pg/mL, P = 0.008). After 16 weeks of treatment, the estradiol level was still higher in the detectable group (51.6 ± 28.6 vs. 38.7 ± 21.7 pg/mL, P = 0.09).
Conclusion: This study showed that 1 mg of estradiol and 2 mg of drospirenone is an appropriate regimen to achieve the desired serum estradiol level. The difference in serum hormonal levels after 4 weeks of treatment could be caused by different basal levels.
목차
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참고문헌 (17)
참고문헌 신청
Anderson AB / 1978 / Comparison of serum oestrogen concentrations in post-menopausal women taking oestrone sulphate and oestradiol / Br Med J 1 : 140 ~ 142
Archer DF / 2001 / Effects of lower doses of conjugated equine estrogens and medroxyprogesterone acetate on endometrial bleeding / Fertil Steril 75 : 1080 ~ 1087
Archer DF / 2005 / Long-term safety of drospirenone-estradiol for hormone therapy: a randomized, double-blind, multicenter trial / Menopause 12 : 716 ~ 727
Blode H / 2000 / A 1-year pharmacokinetic investigation of a novel oral contraceptive containing drospirenone in healthy female volunteers / Eur J Contracept Reprod Health Ca
Fotherby K / 1991 / Intrasubject variability in the pharmacokinetics of ethynyloestradiol / J Steroid Biochem Mol Biol 38 : 733 ~ 736
Archer DF / 2001 / Effects of lower doses of conjugated equine estrogens and medroxyprogesterone acetate on endometrial bleeding / Fertil Steril 75 : 1080 ~ 1087
Archer DF / 2005 / Long-term safety of drospirenone-estradiol for hormone therapy: a randomized, double-blind, multicenter trial / Menopause 12 : 716 ~ 727
Blode H / 2000 / A 1-year pharmacokinetic investigation of a novel oral contraceptive containing drospirenone in healthy female volunteers / Eur J Contracept Reprod Health Ca
Fotherby K / 1991 / Intrasubject variability in the pharmacokinetics of ethynyloestradiol / J Steroid Biochem Mol Biol 38 : 733 ~ 736
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