지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Ezrin, a membrane cytoskeleton linking protein, is a member of ezrin/radixin/moesin (ERM) that regulates cell shape, motility and cell to cell interaction via linking the contractile elements of the cell to transmembrane proteins. Ezrin, through this mechanism, has been thought to play an important role in cancer progression and distant metastasis. In addition, high levels of ezrin expression have been noted in many cancers, such as breast, colon, osteosarcoma, and prostate cancer. Gynecologic cancer cells, with high levels of ezrin expression, have more invasive potential than that of the lower levels of ezrin expressed cancer cells. High levels of ezrin expression are also related to the advanced histological grade and poor outcome. Recently, several reports have also demonstrated that ezrin expression is enhanced and almost localized at the membranous portion in high stage tumor cells and metastatic gynecologic cancer cells. Therefore, in the near future, ezrin levels and its cellular location might serve as essential markers for the metastasis of gynecologic cancers.
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참고문헌 (26)
참고문헌 신청
Arnold JM / 2001 / Reduced expression of intercellular adhesion molecule-1 in ovarian adenocarcinomas / Br J Cancer 85 : 1351 ~ 1358
Bretscher A / 1995 / Soluble ezrin purified from placenta exists as stable monomers and elongated dimers with masked C-terminal ezrin-radixin-moesin association domains / Bi
Bretscher A / 2002 / ERM proteins and merlin : integrators at the cell cortex / Nat Rev Mol Cell Biol 3 : 586 ~ 599
Bruce B / 2007 / Expression of the cytoskeleton linker protein ezrin in human cancers / Clin Exp Metastasis 24 : 69 ~ 78
Buda A / 2003 / Role of ifosfamide in cervical cancer : an overview / Oncology 65 (Suppl 2) : 63 ~ 66
Bretscher A / 1995 / Soluble ezrin purified from placenta exists as stable monomers and elongated dimers with masked C-terminal ezrin-radixin-moesin association domains / Bi
Bretscher A / 2002 / ERM proteins and merlin : integrators at the cell cortex / Nat Rev Mol Cell Biol 3 : 586 ~ 599
Bruce B / 2007 / Expression of the cytoskeleton linker protein ezrin in human cancers / Clin Exp Metastasis 24 : 69 ~ 78
Buda A / 2003 / Role of ifosfamide in cervical cancer : an overview / Oncology 65 (Suppl 2) : 63 ~ 66
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