지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives: This study was aimed to establish the most effective premature ovarian failure (POF) mouse model using Cyclophosphamide (CTX), busulfan (Bu), and cisplatin considering treatment duration of anticancer drugs and natural recovery time.Methods: POF was induced by intraperitoneally injecting CTX (120 mg/kg)/Bu (12 mg/kg) for 1 to 4 weeks or cisplatin (2 mg/kg) for 3 to 14 days to C57BL/6 female mice aged 6 to 8 weeks. Controls were injected with equal volume of saline for the same periods. Body weight was measured every week, and ovarian and uterine weights were measured after the last injection of anticancer drug. To assess ovarian function, POF-induced mice were superovulated with pregnant mare serum gonadotropin and human chorionic gonadotropin, and then mated with male. After 18 hours, zygotes were retrieved and cultured for 4 days. Finally, the mice were left untreated for a period of times after the final injection of anticancer drug, and the time for natural recovery of ovarian function was evaluated. Results: After 2 weeks of CTX/Bu injection, ovarian and uterine weights, and ovarian function were decreased sharply. Cisplatin treatment for 10 days resulted in a significant decrease in ovarian and uterine weight, and ovarian function. When POF was induced for at least 2 weeks for CTX/Bu and for at least 10 days for cisplatin, ovarian function did not recover naturally for 2 weeks and 1 week, respectively.Conclusions: These results suggest that CTX/Bu should be treated for at least 2 weeks and cisplatin for at least 10 days to establish the most effective primary ovarian insufficiency mouse model.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Welt CK. / 2008 / Primary ovarian insufficiency : a more accurate term for premature ovarian failure / Clin Endocrinol (Oxf) 68:499~509
Norling A / 2014 / Identification of a duplication within the GDF9 gene and novel candidate genes for primary ovarian insufficiency(POI)by a customized highresolution array comparative genomic hybridization platform / Hum Reprod 29:1818~1827
Cox L / 2014 / Primary ovarian insufficiency : an update / Int J Womens Health 6:235~243
Nelson LM. / 2009 / Clinical practice. Primary ovarian insufficiency / N Engl J Med 360:606~614
Qin Y / 2012 / ESR1, HK3 and BRSK1 gene variants are associated with both age at natural menopause and premature ovarian failure / Orphanet J Rare Dis 7:5
Norling A / 2014 / Identification of a duplication within the GDF9 gene and novel candidate genes for primary ovarian insufficiency(POI)by a customized highresolution array comparative genomic hybridization platform / Hum Reprod 29:1818~1827
Cox L / 2014 / Primary ovarian insufficiency : an update / Int J Womens Health 6:235~243
Nelson LM. / 2009 / Clinical practice. Primary ovarian insufficiency / N Engl J Med 360:606~614
Qin Y / 2012 / ESR1, HK3 and BRSK1 gene variants are associated with both age at natural menopause and premature ovarian failure / Orphanet J Rare Dis 7:5
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Effects and Mechanism of AP39 on Ovarian Functions in Rats Exposed to Cisplatin and Chronic Immobilization Stress
대한폐경학회지
2024 .08
-
Mesenchymal stem cells for restoration of ovarian function
Clinical and experimental reproductive medicine : CERM
2019 .01
-
Does bilateral uterine artery ligation have negative effects on ovarian reserve markers and ovarian artery blood flow in women with postpartum hemorrhage?
Clinical and experimental reproductive medicine : CERM
2019 .01
-
The Importance of Education regarding the Effects of Anticancer Treatment on Fertility and Ovarian Function in the Female Patients with Breast Cancer
대한폐경학회지
2019 .01
-
HPVSC-derived cyclophilin-A can recover ovarian function in mice with cyclophosphamide-induced premature ovarian failure
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Prior uterine myoma and risk of ovarian cancer: a population-based case-control study
Journal of Gynecologic Oncology
2019 .01
-
난소암 치료에 대한 한의 임상 가이드라인
대한암한의학회지
2016 .01
-
Novel Directions in Adjuvant Chemotherapy for Early Stage Epithelial Ovarian Cancer
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Ovarian Cancer in Children and Adolescents: Treatment and Reproductive Outcomes
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Lycopene Protects Against Spontaneous Ovarian Cancer Formation in Laying Hens
대한암예방학회지
2018 .01
-
Evaluation of Effects of Metformin in Primary Ovarian Cancer Cells
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Do we need a better marker for successful ovarian cancer surgery?
Journal of Gynecologic Oncology
2017 .01
-
Ultrasonographic ovarian mass scoring system for predicting malignancy in pregnant women with ovarian mass
Obstetrics & Gynecology Science
2022 .01
-
난소암 여성의 투병과정 : 죽음의 굴레에 묶인 채 존재가치 찾아가기
성인간호학회지
2018 .12
-
Two Cases of Primary Ovarian Insufficiency Accompanied by High Serum Anti-Mullerian Hormone Levels and Preservation of Ovarian Follicles
대한폐경학회지
2020 .01
-
Current status and future directions of ovarian cancer prognostic models
Journal of Gynecologic Oncology
2021 .01
-
Data Mining for Identification of Molecular Targets in Ovarian Cancer
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Epigenetic modification of α-N-acetylgalactosaminidase enhances cisplatin resistance in ovarian cancer
The Korean Journal of Physiology & Pharmacology
2018 .01
-
A Successful Live Birth From a Vitrified Oocyte for Fertility Preservation of a Patient With Borderline Ovarian Tumor Undergoing Bilateral Ovarian Surgery: A Case Report
Journal of Korean Medical Science
2024 .01
-
난소암 치료 이행성 연구의 최신 동향
대한의사협회지
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0