지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 72 - 80 (9page)
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초록· 키워드
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The purpose of the present study was to investigate the effects of familiar exercise and novel exercise on motor function after intracerebral hemorrhage (ICH) in rats. The rats were subjected to a unilateral striatal ICH via collagenase infusion. The rats were randomly divided into the following three groups: the CON (control group; rested one week post-ICH), the FE (familiar exercise group; familiar exercise was performed two weeks after one-week post-ICH period), and NE (novel exercise group; novel exercise was performed two weeks after one-week post-ICH period). We measured neurological behavior using a ladder rung walking test and a beam walking test; we measured the level of nerve growth factor (NGF) using immunohistochemistry and western blot analysis. We performed a one-way ANOVA test to analyze the scores obtained from the neurological behavior tests and the differences of NGF protein levels among the three groups. In the present study, the FE group and the NE group showed significant improvement during the neurological behavior tests and in their expression of NGF protein level, as compared to the CON group. Especially, NE group more increase than FE group in neurological behavior tests, the expression of NGF on motor cortex. In conclusion, these results suggest that, after ICH, familiar exercise and novel exercise enhance motor function and, novel exercise is more effective than familiar exercise.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Andres RH / 2008 / Cell replacement therapy for intracerebral hemorrhage / Neurosurg Focus 24 (3-4) : E16 ~
Ang ET / 2007 / Potential therapeutic effects of exercise to the brain / Curr Med Chem 14 (24) : 2564 ~ 2571
Barbay S / 2006 / Behavioral and neurophysiological effects of delayed training following a small ischemic infarct in primary motor cortex of squirrel monkeys / Exp Brain Res
Beray-Berthat V / 2010 / Long-term histological and behavioural characterisation of a collagenase-induced model of intracerebral haemorrhage in rats / J Neurosci Methods 191
Bradford MM / 1976 / A rapid sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding / Anal Biochem 72 : 248 ~
Ang ET / 2007 / Potential therapeutic effects of exercise to the brain / Curr Med Chem 14 (24) : 2564 ~ 2571
Barbay S / 2006 / Behavioral and neurophysiological effects of delayed training following a small ischemic infarct in primary motor cortex of squirrel monkeys / Exp Brain Res
Beray-Berthat V / 2010 / Long-term histological and behavioural characterisation of a collagenase-induced model of intracerebral haemorrhage in rats / J Neurosci Methods 191
Bradford MM / 1976 / A rapid sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding / Anal Biochem 72 : 248 ~
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