지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 83 - 92 (10page)
이용수
초록· 키워드
오류제보하기
Osteoarthritis is a degenerative joint disease and is led to physical disability. Yet the development of effective disease-modifying treatments has lagged. In this study, I examined the effect of physical therapeutic intervention through microcurrent stimulation and attempt to find which degree of intensity, either 25 ㎂ or 500 ㎂ with a regular 5 pps pulse, is more effective in the osteoarthritis. Osteoarthritis was induced with a mixture of 2% carrageenan and 2% kaolin in 26 male Sprague-Dawley rats. The mixture (0.1 ㎖) was injected into the intra-articular capsule of knee joint once a week for three weeks. Five animals did not show degenerative changes by radiological findings and excluded in the following experiment. Osteoarthritic animals were randomly divided into 3 groups(n1, n2, n3=7/each): untreated, treated with 25 ㎂, treated with 500 ㎂. All experimental groups received microcurrent stimulation for four weeks (15 min/day, 5 days/week). The ethological inspection of foot print analysis on the walking corridor was accomplished every week. Histological preparations and immunohistochemical staining with insulin-like growth factor-1 were also done in the articular cartilages. All of these parameters were compared with those of osteoarthritic control group (n=7). The ethological inspection of foot print analysis revealed that changes of walking track (paw width) and stride length was significantly increased in both experimental groups. The better results were observed in experimental group treated with 25 ㎂ intensity without significance than group treated with 500 ㎂. Histological preparations disclosed that routine hyaline cartilage of articular surface were altered to fibrous cartilage in untreated group and experimental group treated with 500 ㎂ intensity. But a little changes were seen in experimental group treated with 25 ㎂ intensity. Immunolocalization of insulin-like growth factor-1 was simultaneously decreased according to the duration of osteoarthritis, and did not show significant difference among the groups. In this study discovered that the microcurrent stimulation, especially 25 ㎂ intensity, had a positive effect by the ethological inspection, histological and immunohistochemical stainings. These results suggest that microcurrent stimulation with low-intensity might be effective in the promotion of healing process for the osteoarthritis.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Bang HS / 2007 / The effect of microcurrent electrical stimulation on the articular cartilage rcovery in osteoarthritis / J Kor Soc Phys Med 2 (2) : 151 ~ 159
Barker AT / 1982 / The glabrous epidermis of cavies contains a powerful battery / Am J Physiol 242 (3) : 358 ~ 366
Bayat M / 2006 / Experimental wound healing using microamperage electrical stimulation in rabbits / J Rehabil Res Dev 43 (2) : 219 ~ 226
Brenner SS / 2004 / Osteoarthritis of the knee: Clinical assessments and inflammatory markers / Osteoarthritis Cartilage 12 (6) : 469 ~ 475
Butler SH / 1992 / limited arthritic model for chronic pain studies in the rat / Pain 48 (1) : 73 ~ 81
Barker AT / 1982 / The glabrous epidermis of cavies contains a powerful battery / Am J Physiol 242 (3) : 358 ~ 366
Bayat M / 2006 / Experimental wound healing using microamperage electrical stimulation in rabbits / J Rehabil Res Dev 43 (2) : 219 ~ 226
Brenner SS / 2004 / Osteoarthritis of the knee: Clinical assessments and inflammatory markers / Osteoarthritis Cartilage 12 (6) : 469 ~ 475
Butler SH / 1992 / limited arthritic model for chronic pain studies in the rat / Pain 48 (1) : 73 ~ 81
이 논문의 저자 정보
최근 본 자료
댓글(0)
0