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Objectives: To introduce a protocol of Mobi-kids study which was aimed to examine an association betweenradiofrequency (RF) radiation exposure by mobile phone use and brain tumor risk in children and adolescents. Methods: The Mobi-kids study was a multinational matched case control study using a standardized protocolwith the number of subjects targeted about 1,000 cases and 2,000 controls aged 10 to 24. In Mobi-Kids Korea,the source population was restricted to Seoul, Incheon, and Gyeonggi-do province. Eligible cases of primary brain tumor (glioma, meningioma, and others) were diagnosed from January 2012 to June 2015. Eligible controlswere appendicitis patients operated during the study period. Two controls were matched on age, gender, andstudy region for 1 case. Information about pattern and history of mobile phone use and other covariates wereobtained by face to face interview by trained interviewer. The Mobi-kids study has been involved in Mobi-expoas a validation study about mobile phone use, XGridmaster to localize tumor in the brain for RF energycalculation, and histological review for validation of diagnosis. Results: The Mobi-kids was the first and largest study in children and adolescents to estimate risk of brain tumorin association with the RF energy absorption in the brain estimated by mobile phone use. Forty-six-cases and54 controls were collected as of September 2014 in Korea. Conclusions: The meaningful results of the study were expected because of the largest sample size, high validityof EMF exposure assessment as well as the susceptible study populationof children and adolescents.

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