지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 407 - 412 (6page)
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초록· 키워드
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Objectives: The internal dose of ethyl parabens is important in order to evaluate the risk of this chemical.
However, there are little PK model data for parabens to apply this. This experiment attempted PK modeling toascertain PK values.
Methods: Twenty mg/kg ethyl paraben was administered orally to Sprague-Dawley rats at the same point in time.
The rats were sacrificed at times 0, 15, 30 and minutes, and 1, 2, 4, 8, 12, 24 hours after oral gavage. Blood andurine were collected and pretreated for analysis. Accuracy, precision and LOD (limit of detection) were calculatedfor this analysis. Ethyl paraben, detected by HPLC-MS, was applied to PK modeling using Berkeley Madonna.
Results: This study showed 100.1-103.7% accuracy, 1.4-3.7% precision and a 1.0 ng/mL limit of detection.
Orally administered ethyl paraben reached maximum concentration after 30 minutes of dosing in serum andurine of rats. The concentrations were 2,354 ng/mL in serum and 386,000 ng/mL in urine samples. These peakconcentrations were excreted after one hour of intubation over 12 hours. For the pharmacokinetic parameters ofethyl paraben revealed using Berkeley Madonna, the absorption rate was 5.539/hour, the excretion rate was0.048/hour, the half-life was 14.441 hours and AUC was 481,186 ng hour/mL.
Conclusion: Orally administered ethyl paraben was absorbed rapidly in rats and excreted in urine. Thischemical, ethyl paraben, accumulated in the body but was excreted over 12 hours after dosing.
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참고문헌 (14)
참고문헌 신청
Andersen ME / 1997 / Pharmacodynamic model of the rat estrus cycle in relation to endocrine disruptors / J Toxicol Environ Health 52 (3) : 189 ~ 209
Aubert N / 2012 / Systemic exposure to parabens: pharmacokinetics, tissue distribution, excretion balance and plasma metabolites of [14C]-methyl-, propyl- and butylparaben in
Castelain F / 2012 / Parabens: a real hazard or a scare story? / Eur J Dermatol 22 (6) : 723 ~ 727
Clewell HJ / 2001 / Comparison of cancer risk estimates for vinyl chloride using animal and human data with a PBPK model / Sci Total Environ 274 (1-3) : 37 ~ 66
Franks SJ / 2006 / Physiologically based pharmacokinetic modelling of human exposure to 2-butoxyethanol / Toxicol Lett 162 (2-3) : 164 ~ 173
Aubert N / 2012 / Systemic exposure to parabens: pharmacokinetics, tissue distribution, excretion balance and plasma metabolites of [14C]-methyl-, propyl- and butylparaben in
Castelain F / 2012 / Parabens: a real hazard or a scare story? / Eur J Dermatol 22 (6) : 723 ~ 727
Clewell HJ / 2001 / Comparison of cancer risk estimates for vinyl chloride using animal and human data with a PBPK model / Sci Total Environ 274 (1-3) : 37 ~ 66
Franks SJ / 2006 / Physiologically based pharmacokinetic modelling of human exposure to 2-butoxyethanol / Toxicol Lett 162 (2-3) : 164 ~ 173
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