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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 379 - 385 (7page)
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This study was aimed to investigate the estrogenic activity of Di-(2-ethylhexyl) adipate (DEHA) using immatured type uterotrophic assay. SD rats were treated with DEHA (40, 200, 1000 mg/kg/day), estradiol-3-benzoate (EB) (1mg/kg/day) as positive control on the assay. In immatured-type uterotrophic assay, relative organ weights of kidney and reproductive organs such as ovary at high-dose group were significantly increased compared to those of vehicle control group. DEHA did not influence the levels of serum FSH and LH, and uterine morphological changes such as luminal epithelial height, myometrial thickness and numbers of uterine gland, and BrdU indices. In these results, there was no significant variation by DEHA treatment, suggesting that DEHA appears not to be a endocrine disrupter with estrogenic activity.
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참고문헌 (24)
참고문헌 신청
[학술지(정기
Ashby J / 1997 / of raloxifene in immature and ovariectomized rat uterotrophic assays 25 (3) : 226 ~ 231
Choi K / 2004 / The Reproductive Toxicity by Combined Treatment of Bisphenol A and Butyl Benzyl Phthalate During Gestation, Lactation Period in Rats 30 (2) : 71 ~ 78
EPA EDSTAC / 1998 / Endocrine Disrupotr Screening and Testing Advisory Committee Final Report
Han S. Y / 2000 / Study on the estrogenic activity of di-(2-ethylhexyl) adipate in E-screen assay and uterotrophic assay 32 (4) : 964 ~ 969
Ashby J / 1997 / of raloxifene in immature and ovariectomized rat uterotrophic assays 25 (3) : 226 ~ 231
Choi K / 2004 / The Reproductive Toxicity by Combined Treatment of Bisphenol A and Butyl Benzyl Phthalate During Gestation, Lactation Period in Rats 30 (2) : 71 ~ 78
EPA EDSTAC / 1998 / Endocrine Disrupotr Screening and Testing Advisory Committee Final Report
Han S. Y / 2000 / Study on the estrogenic activity of di-(2-ethylhexyl) adipate in E-screen assay and uterotrophic assay 32 (4) : 964 ~ 969
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