지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 130 - 137 (8page)
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초록· 키워드
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Objectives: The OECD QSAR Application Toolbox was developed by the Organisation for Economic Cooperation and Development (OECD) to facilitate the practical use of QSAR approaches in regulatory contexts as well as to reduce the need for additional animal testing. In this study, human health and the ecotoxicity of chemicals were predicted by applying the OECD QSAR Application Toolbox and the results were compared with experimental data in order to evaluate the applicability of this program.
Methods: Read-across, trend analysis, and QSAR of OECD QSAR Application Toolbox were used for the prediction of toxicity.
Results: The toxicity prediction was conducted on 6,354 chemicals for which toxicity data have been produced on the six endpoints of skin sensitization, skin irritation, eye irritation, mutagenicity, and acute toxicities of fish and Daphnia. From the total of 6,354, we obtained prediction results for 1,621 chemicals (25.5%).
Conclusions: The predicted properties of mutagenicity, skin sensitization, and acute aquatic toxicities were reasonably good when compared with experimental data, but other endpoints were not due to the limitation of applicable chemical groups.
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참고문헌 (23)
참고문헌 신청
Brown AC / 1868 / On the connection between chemical constitution and physiological action; with special reference to the physiological action of the salts of the ammonium b
Devillers J / 2010 / Evaluation of the OECD QSAR Application Toolbox and Toxtree for estimating the mutagenicity of chemicals. Part 2. α-β unsaturated aliphatic aldehydes /
Devillers J / 2011 / Structural alerts for estimating the carcinogenicity of pesticides and biocides / SAR and QSAR in Environmental Research 22 : 89 ~ 106
EC / 1986 / Council Directive 86/609/EEC of 24 November 1986 on the approximation of laws, regulations and administrative provisions of the Member States regarding the protection of an
EC / 2006 / Registration, evaluation, authorisation and restriction of chemicals (REACH), regulation (EC) No 1907/2006 of the European Parliament and of the Council
Devillers J / 2010 / Evaluation of the OECD QSAR Application Toolbox and Toxtree for estimating the mutagenicity of chemicals. Part 2. α-β unsaturated aliphatic aldehydes /
Devillers J / 2011 / Structural alerts for estimating the carcinogenicity of pesticides and biocides / SAR and QSAR in Environmental Research 22 : 89 ~ 106
EC / 1986 / Council Directive 86/609/EEC of 24 November 1986 on the approximation of laws, regulations and administrative provisions of the Member States regarding the protection of an
EC / 2006 / Registration, evaluation, authorisation and restriction of chemicals (REACH), regulation (EC) No 1907/2006 of the European Parliament and of the Council
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