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자료유형
학술저널
저자정보
저널정보
한국환경보건학회 한국환경보건학회지 한국환경보건학회지 제40권 제4호
발행연도
2014.1
수록면
294 - 303 (10page)

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Objectives: Excretion and tissue distribution of titanium oxide nanoparticles were evaluated in rats after oraladministration. The relation between toxicity and systemic concentration of nanoparaticles was investigated. Methods: Rats were orally treated with titanium oxide nanoparticles (10, 100 mg/kg) for five consecutive days. General toxicity, blood chemistry, and serum biochemical analysis were analyzed. Titanium concentration inliver, kidney, lung, urine and feces were measured and histopathology was performed in these organs. Results: Induction of toxicological parameters was not observed and titanium nanoparticles were excreted viafeces. Conclusion: Absorption of titanium oxide nanoparticles via the gastrointestinal tract after oral administrationwas very poor and systemic concentration of titanium oxide nanoparticles was not elevated. Titanium oxidenanoparticles did not cause toxicities in rats after oral administration.

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