지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 265 - 278 (14page)
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초록· 키워드
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Microbes such as bacteria, fungi, archaea, protists, and viruses are ubiquitous and people are exposed tothem continuously. Endotoxin is a component of the outer membrane of Gram-negative bacteria and apotent proinflammaotry substance. When a person is exposed to environmental endotoxin, an innateimmune response is initiated upon the initial recognition and this response produces various inflammatorymediators and recruits inflammatory cells to the exposed tissues. A purified chemical form of endotoxinis called lipopolysaccharide (LPS), and the lipid A portion of the molecule is a biologically active moiety.
Exposure to endotoxin may result in various complex health effects depending on time, route, and dose ofexposure, as well as host susceptibility. Gene-environment interactions play important roles in healtheffects of endotoxin exposure, e.g. development or aggravation of asthma. To accurately assess exposureto endotoxin in environmental or epidemiologic studies, methods of sampling, extraction, and analysis mustbe carefully selected since the selected methods may substantially affect analytical results and there is nointernationally-agreed standard method to date. The lack of a standardized method hampers theestablishment of exposure-response relationships. While an internationally-agreed health-based exposurelimit does not exist, the Dutch Expert Committee on Occupational Safety recently recommended 90 EU/m3as a health-based occupational exposure limit. The current article reviews various scientific issues on howwe measure environmental endotoxin and the health effects of endotoxin exposure.
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참고문헌 (88)
참고문헌 신청
Simpson JL / 2008 / Innate immunity in asthma / Pediatr Respir Rev 9:263~270
Dawson ME / 1993 / Depyrogenation / Incoporated Press
Heumann D / 2002 / Initial responses to endotoxins and Gram-negative bacteria / Clin Chim Acta 323(1-2):59~72
Rietschel ET / 1992 / Bacterial endotoxins / Sci Am 267(2):54~61
Beutler B / 2003 / Innate immune sensing and its roots: the story of endotoxin / Nat Rev Immunol 3(2):169~176
Dawson ME / 1993 / Depyrogenation / Incoporated Press
Heumann D / 2002 / Initial responses to endotoxins and Gram-negative bacteria / Clin Chim Acta 323(1-2):59~72
Rietschel ET / 1992 / Bacterial endotoxins / Sci Am 267(2):54~61
Beutler B / 2003 / Innate immune sensing and its roots: the story of endotoxin / Nat Rev Immunol 3(2):169~176
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