지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 360 - 368 (9page)
이용수
초록· 키워드
오류제보하기
Objectives: Phthalates are used in a large variety of products including as coatings of pharmaceutical tablets,film formers, stabilizers, dispersants, emulsifying agents, and suspending agents. They have been the subject of great public concern in recent years. The extensive uses of this material have attracted attention and issues regarding its safety have been raised.
Methods: In this study, three types of phthalate skin permeation were studied using matrixes such as ointments, creams and lotions in vitro. The absorption of phthalate diesters [Dimethyl phthalate (DMP), Din-propyl phthalate (DPP) and Di-n-pentyl phthalate (DNPP)] using film former has been measured in vitro through rat skin. Epidermal membranes were set up in Franz diffusion cells and their permeability to PBS measured in order to establish the integrity of the skin before the phthalates were applied to the epidermal surface.
Results: Absorption rates for each phthalate ester were determined and permeability assessment made to quantify any irreversible alterations in barrier function due to contact with the esters. Types of phthalate in vitro experimental results quickly appeared in the following order DMP > DPP ≥ DNPP.
Conclusions: In the experimental results, lotion> cream> ointment, and the permeation rate of lotion with a great amount of moisture was the fastest. Skin permeation rate is generally influenced by the chemical characteristics of a given chemical, such as molecular weight and lipophilicity. As the esters became more lipophilic and less hydrophilic, the rate of absorption decreased.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
ATSDS / / Agency for Toxic Substances and Disease Registry Safeguarding Communities from Chemical Exposures / ATSDA Press : 1 ~ 38
Anissimov YG / 2001 / Diffusion modeling of percutaneous absorption kinetics. 2. Finite vehicle volume and solvent deposited solids / J Pharm Sci 90 (4) : 504 ~ 520
Barr DB / 2003 / Assessing human exposure to phthalates using monoesters and their oxidized metabolites as biomarkers / Environ. Health Perspect 111 (9) : 1148 ~ 1151
Brain KR / 2005 / Percutaneous penetration of diethanolamine through human skin in vitro: application from cosmetic vehicles / Food Chem Toxicol 43 (5) : 681 ~ 690
Brien O / 1978 / Electrophoretic mobility of a spherical colloidal particle / J Chem Soc Faraday Trans 74 (2) : 1607 ~ 1626
Anissimov YG / 2001 / Diffusion modeling of percutaneous absorption kinetics. 2. Finite vehicle volume and solvent deposited solids / J Pharm Sci 90 (4) : 504 ~ 520
Barr DB / 2003 / Assessing human exposure to phthalates using monoesters and their oxidized metabolites as biomarkers / Environ. Health Perspect 111 (9) : 1148 ~ 1151
Brain KR / 2005 / Percutaneous penetration of diethanolamine through human skin in vitro: application from cosmetic vehicles / Food Chem Toxicol 43 (5) : 681 ~ 690
Brien O / 1978 / Electrophoretic mobility of a spherical colloidal particle / J Chem Soc Faraday Trans 74 (2) : 1607 ~ 1626
이 논문의 저자 정보
최근 본 자료
댓글(0)
0