메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
저널정보
한국환경보건학회 한국환경보건학회지 한국환경보건학회지 제31권 제3호
발행연도
2005.1
수록면
227 - 233 (7page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
This study was designed to determine the estrogenic effect of the pharmaceuticals on several measures of endocrine function in adult fish (Oryzias latipes) that was induced by residual pharmaceuticals. 17-estradiol was used positive control that was induced vitellogenin (Vtg) in male fish. Some common pharmaceuticals were used caffeine, ketoconazole, acetaminophen and diltiazem. Vtg was qualified and quantified through Western blot and ELISA. Following SDS gel electrophoresis, the dominant protein band was identified to molecular weight approximately 205 kDa in whole body samples of vitellogenic female. As a exposed 17-estradiol, female fish didn't showed significant difference, but 3-5 days exposure of 17-estradiol to male fish induced 63.07‰ of total protein, the value was elevated than control male fish (0.76‰) and was showed a large significant difference p<0.01. In case of general pharmaceuticals, female fish didn’t showed significant difference, while male fish did showed significant difference. Vtg was induced significantly at male fish over caffeine 2 ppm. Same as ketoconazole 10 ppm, acetaminophen 4 ppm, diltiazem 1pm induced vtg significantly at male fish. This study confirmed Vtg by whole body samples of pharmaceutical compounds even at low concentration (ppm). In addition, the result of each chemical tested in sequence of concentration range, each chemical was increased Vtg concentration in fish when increased exposure range of each. Therefore, if residual pharmaceutic chemucals increase in aquatic environment, that will be a serious problem at fish, human and ecosystem.

목차

등록된 정보가 없습니다.

참고문헌 (13)

참고문헌 신청

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0