지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 550 - 560 (11page)
이용수
초록· 키워드
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Objectives: QSAR methodology was applied to explain two different sets of acceptable daily intake (ADI) data of 74 pesticides proposed by both the USEPA and WHO in terms of setting guidelines for food and drinking water. Methods: A subset of calculated descriptors was selected from Dragon(R) software. QSARs were then developed utilizing a statistical technique, genetic algorithm-multiple linear regression (GA-MLR). The differences in each specific model in the prediction of the ADI of the pesticides were discussed. Results: The stepwise multiple linear regression analysis resulted in a statistically significant QSAR model with five descriptors. Resultant QSAR models were robust, showing good utility across multiple classes of pesticide compounds. The applicability domain was also defined. The proposed models were robust and satisfactory. Conclusions: The QSAR model could be a feasible and effective tool for predicting ADI and for the comparison of logADIEPA to logADIWHO. The statistical results agree with the fact that USEPA focuses on more subtle endpoints than does WHO.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Bermudez-Saldana JM / 2006 / Quantitative structure-activity relationships for the toxicity of organophosphorus and carbamate pesticides to the Rainbow trout Onchorhyncus myk
Bhhatarai, B / 2011 / Model
Blair A / 2011 / Impact of pesticide exposure misclassification on estimates of relative risks in the Agricultural Health Study / Occup Environ Med 68 (7) : 537 ~ 541
Chaudhry, Q / 2007 / Algorithms for (Q)SAR model building; in Quantitative Structure- Activity Relationship (QSAR) for Pesticide Regulatory Purposes / Elsevier : 111 ~
Damalas CA / 2011 / Pesticide Exposure, Safety Issues, and Risk Assessment Indicators / Int J Environ Res Public Health 8 (5) : 1402 ~ 1419
Bhhatarai, B / 2011 / Model
Blair A / 2011 / Impact of pesticide exposure misclassification on estimates of relative risks in the Agricultural Health Study / Occup Environ Med 68 (7) : 537 ~ 541
Chaudhry, Q / 2007 / Algorithms for (Q)SAR model building; in Quantitative Structure- Activity Relationship (QSAR) for Pesticide Regulatory Purposes / Elsevier : 111 ~
Damalas CA / 2011 / Pesticide Exposure, Safety Issues, and Risk Assessment Indicators / Int J Environ Res Public Health 8 (5) : 1402 ~ 1419
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