지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 541 - 549 (9page)
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Objectives: This study was undertaken in order to evaluate a potential mechanism involved in gastro-intestinal problems observed in autistic subjects and uses an animal model of autism investigation.
Methods: BTBR T+tf/J, a mouse strain with typical socio-behavioral characteristics of autistic subjects and FVB mice with highly social behaviors as the control strain were used. Both genders of mice aged three weeks and six months were used from four separate litters for each strain. Serum was prepared following cardiac puncture, and mesenteric lymph nodes were collected for in vitro stimulation and enumeration of major immune cell proportion.
Results: The level of serum IgA was significantly enhanced in six-month-old BTBR mice compared with threeweek-old BTBR, which was not observed with the FVB control mice. The serum IgE level was also higher among BTBR mice than among age-sex matched FVB mice, respectively. Considering the ratio of interleukin-4 vs interferon-gamma production from mesenteric lymph node T cells, skewedness toward type-2 reactivities was observed. In addition, the proportion of B cells in mesenteric lymph nodes was significantly higher in BTBR mice than in FVB mice.
Conclusion: Upregulation of mucosal immunity related with enhanced type-2 immune reactivity observed in BTBR mice could be involved with the etiology of gastro-intestinal abnormalities in autism.
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참고문헌 (25)
참고문헌 신청
Ashwood P / 2004 / A review of autism and the immune response / Clin Develop Immunol 11 (2) : 165 ~ 174
Becker KG. / 2007 / Autism, asthma, inflammation, and the hygiene hypothesis / Med Hypotheses 69 : 731 ~ 740
Blaylock RL / 2008 / A possible central mechanism in autism spectrum disorders, part 1 / Altern Ther Health Med 14 (6) : 46 ~ 53
Blaylock RL / 2009 / A possible central mechanism in autism spectrum disorders, part 2: immunoexcitotoxicity / Altern Ther Health Med 15 (1) : 60 ~ 67
Blaylock RL / 2009 / A possible central mechanism in autism spectrum disorders, part 3: the role of excitotoxin food additives and the synergistic effects of other environmen
Becker KG. / 2007 / Autism, asthma, inflammation, and the hygiene hypothesis / Med Hypotheses 69 : 731 ~ 740
Blaylock RL / 2008 / A possible central mechanism in autism spectrum disorders, part 1 / Altern Ther Health Med 14 (6) : 46 ~ 53
Blaylock RL / 2009 / A possible central mechanism in autism spectrum disorders, part 2: immunoexcitotoxicity / Altern Ther Health Med 15 (1) : 60 ~ 67
Blaylock RL / 2009 / A possible central mechanism in autism spectrum disorders, part 3: the role of excitotoxin food additives and the synergistic effects of other environmen
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