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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 380 - 385 (6page)
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초록· 키워드
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Background: Manganese (Mn) has been found to increase the signal intensity of the globus pallidus (GP) on T1-weighted magnetic resonance images (MRI). We performed this study in order to determine the features of liver disease that correlate with pallidal signal intensities.
Methods: We assessed blood Mn levels and pallidal signals in T1-weighted MRI in 49 patients with liver cirrhosis and 23 healthy controls.
Results: Increased signal intensity in the GP was observed in 30 of 49 (61.2%) patients with liver cirrhosis, with the pallidal index (PI) in patients with Child-Pugh classes B and C differing significantly from the PI in controls.
Multiple linear regression analysis showed that blood Mn concentrations and Child-Pugh scores in cirrhotics were significantly associated with increased PI after controlling for other confounders (p<0.05 each).
Conclusions: Pallidal signals on T1-weighted MRI are mainly observed in advanced liver cirrhosis. The present study suggests that advanced liver cirrhosis may be a human model for manganism.
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참고문헌 (24)
참고문헌 신청
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Baldwin S / 1994 / Low volume microwave digestion of marine biological tissues for the measurement of trace elements / Analyst 119 (8) : 1701 ~ 1704
Bang S-J / 2007 / High pallidal T1 signal is rarely observed in obstructive jaundice, but is frequently observed in liver cirrhosis / J Occup Health 49 (4) : 268 ~ 272
Butterworth RF / 1995 / Manganese toxicity, dopaminergic dysfunction and hepatic encephalopathy / Metab Brain Dis 10 (4) : 259 ~ 267
Choi Y / 2005 / Whole blood and red blood cell manganese reflected signal intensities of T1-weighted MRI better than plasma manganese in liver cirrhotics / J Occup Health 47
Baldwin S / 1994 / Low volume microwave digestion of marine biological tissues for the measurement of trace elements / Analyst 119 (8) : 1701 ~ 1704
Bang S-J / 2007 / High pallidal T1 signal is rarely observed in obstructive jaundice, but is frequently observed in liver cirrhosis / J Occup Health 49 (4) : 268 ~ 272
Butterworth RF / 1995 / Manganese toxicity, dopaminergic dysfunction and hepatic encephalopathy / Metab Brain Dis 10 (4) : 259 ~ 267
Choi Y / 2005 / Whole blood and red blood cell manganese reflected signal intensities of T1-weighted MRI better than plasma manganese in liver cirrhotics / J Occup Health 47
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