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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
한국환경보건학회 한국환경보건학회지 한국환경보건학회지 제37권 제6호
발행연도
2011.1
수록면
429 - 439 (11page)

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Objectives: Ethylene oxide (EtO) is classified as a human carcinogen, but EtO is still widely used to sterilize heat-sensitive materials in hospitals. Employees working around sterilizers are exposed to EtO after sterilization. The aim of the present study was to assess the exposure of EtO level, coupled with occupationally induced micronuclei from hospital workers. The influence of genetic polymorphisms of detoxifying genes (GSTT1 and GSTM1) and DNA repair genes (XRCC1 and XRCC3) on the frequencies of micronuclei in relation to exposure of EtO was also investigated. Methods: The study population was composed of 35 occupationally exposed workers to EtO, 18 student controls and 44 unexposed hospital controls in Korea. Exposure to EtO is measured by passive personal samplers. We analyzed the frequencies of micronuclei by performing cytokinesis-block micronucleus assay (CBMN assay) and GSTM1, GSTT1, XRCC1, and XRCC3 were also genotyped by performing polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP). Results: The frequencies of micronuclei in EtO exposure group, student controls and hospital controls were 18.00 ± 7.73, 10.47 ± 7.96 and 13.86 ± 6.35 respectively and their differences were statistically significant, but no significant differences according to the level of EtO were observed. There was a dose-response relationship between the frequencies of micronuclei and cumulative dose of EtO, but no significantly differences were observed. We also investigated the influence of genetic polymorphisms (GSTM1, GSTT1, XRCC1, and XRCC3) on the frequencies of micronuclei, but there were no differences in the frequencies of micronuclei by genetic polymorphisms. Conclusions: The frequencies of micronuclei in EtO exposure group was significantly higher than control groups. A dose-response relationship was found between the level of EtO exposure and the frequencies of micronuclei, but no statistically differences were observed. We also found that the frequencies of micronuclei were increased according to cumulative EtO level. There was no association of the genetic GSTM1, GSTT1, XRCC1, and XRCC3 state with the frequency of micronuclei induced by EtO exposure.
#Ethylene oxide #EtO) #Genetic polymorphism #Glutathione S-transferase #GST) #Hospital workers #Micronuclei #MN) #X-ray repair cross-complementing group #XRCC)

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참고문헌 (22)

참고문헌 신청
Agurell E / 1991 / Genotoxic effects of ethylene oxide and propylene oxide: a comparative study / Mutat Res 250 (1) : 229 ~ 237 google schola Anonymous / 2006 / Guide to occupational exposure values 2006 / ACGIH : 58 ~ google schola Catalan J / 1998 / Age-depende google schola Chang SH / 1998 / Sister chromatid exchanges in workers occupationally exposed to ethylene oxide / Korean J Occup Environ Med 10 (4) : 428 ~ 437 google schola Fenech M / 1997 / A more comprehensive application of the micronucleus technique for biomonitoring of genetic damage rates in humanpopulations-experiences from the Chernobyl google schola

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