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The growing nuclear threat has amplified the need for developing diverse and accurate nuclear forensicsanalysis techniques to strengthen nuclear security measures. The work presented here is part of aresearch effort focused on developing a methodology for reactor-type discrimination of weapons-gradeplutonium. To verify the developed methodology, natural UO2 fuel samples were irradiated in a thermalneutron spectrum at the University of Missouri Research Reactor (MURR) and produced approximately20 mg of weapons-grade plutonium test material. Radiation transport simulations of common thermalreactor types that can produce weapons-grade plutonium were performed, and the results are presentedhere. These simulations were needed to verify whether the plutonium produced in the natural UO2 fuelsamples during the experimental irradiation at MURR was a suitable representative to plutonium producedin common thermal reactor types. Also presented are comparisons of fission product and plutoniumconcentrations obtained from computational simulations of the experimental irradiation at MURRto the nondestructive and destructive measurements of the irradiated natural UO2 fuel samples. Gammaspectroscopy measurements of radioactive fission products were mostly within 10%, mass spectroscopymeasurements of the total plutonium mass were within 4%, and mass spectroscopy measurements ofstable fission products were mostly within 5%.

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