지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Nano and micro structure-based biosensors are promising tool for label-free detection of biomolecular interactions with great accuracy. This review gives a brief survey on nano and micro platforms to sense a variety of analytes such as DNA, proteins and viruses. Among incredible nano and micro structure for bio-analytical applications, the scope of this paper will be limited to micro and nano resonators and nanowire field-effect transistors. Nanomechanical motion of the resonators transducers biological information to readable signals. They are commonly combined with an optical, capacitive or piezo-resistive detection systems. Binding of target molecule to the modified surface of nanowire modulates the current of the nanowire through electrical field-effect. Both detection methods have advantages of label-free, real-time and high sensitive detection. These structures can be extended to fabricate array-type sensors for multiplexed detection and highthroughput analysis. The biosensors based on these structures will be applied to lab-on-a-chip platforms and point-ofcare diagnostics. Basic concepts including detection mechanisms and trends in their fields will be covered in this review.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
D. J. Muller / 2008 / Atomic force microscopy as a multifunctional molecular toolbox in nanobiotechnology / Nat. Nanotechnol 3 : 261 ~ 269
D. W. Chun / 2007 / Detection of the Au thin-layer in the Hz per picogram regime based on the microcantilevers / Sens. Actuat. A 135 : 857 ~ 862
G. H. Wu / 2001 / Bioassay of prostate-specific antigen(PSA)using microcantilevers / Nat. Biotechnol 19 : 856 ~ 860
G. H. Wu / 2001 / Origin of nanomechanical cantilever motion generated from biomolecular interactions / Proc. Natl. Acad. Sci. USA 98 : 1560 ~ 1564
G.G.Stoney / 1909 / The tension of metallic films deposited by electrolysis / Proc. R. Soc. Lond. A 82 : 172 ~ 175
D. W. Chun / 2007 / Detection of the Au thin-layer in the Hz per picogram regime based on the microcantilevers / Sens. Actuat. A 135 : 857 ~ 862
G. H. Wu / 2001 / Bioassay of prostate-specific antigen(PSA)using microcantilevers / Nat. Biotechnol 19 : 856 ~ 860
G. H. Wu / 2001 / Origin of nanomechanical cantilever motion generated from biomolecular interactions / Proc. Natl. Acad. Sci. USA 98 : 1560 ~ 1564
G.G.Stoney / 1909 / The tension of metallic films deposited by electrolysis / Proc. R. Soc. Lond. A 82 : 172 ~ 175
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