지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Hyaluronic acid(HA) hydrogels were synthesized by immersing HA microbeads in phosphate buffered saline solutions having different pH levels to assess the effect of pH on the swelling ratio of HA hydrogels for smart drug delivery systems. No beads were formed when the HA solution(below pH 9) was crosslinked with divinyl sulfone(DVS) because DVS is a basic solution. The variation regarding the size of the microbead was not significant, suggesting that the bead size is not a function of pH(10 ~ 14). However, the pore size of the microbeads decreased with increasing pH from 10 to 14, leading to the surface smoothness and dense network as a result of higher crosslinking. The swelling ratio of hydrogels increased when the pH rose from 2(acidic) to 6(neutral). Afterwards, it decreased with further increasing pH(basic). The lower swelling ratio may be due to the lack of ionization of the carboxyl groups. On the other hand, a higher swelling ratio is likely due to the increased electrostatic repulsions between negatively charged carboxyl groups on different chains. Experimental results suggested that pH-responsive HA hydrogels can be applicable to the controlled drug delivery systems.
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참고문헌 (21)
참고문헌 신청
A. S. Hoffman / 2002 / Hydrogels for biomedical applications / Adv. Drug Deliv. Rev 54 : 3 ~ 12
A.C. Jen / 1996 / Review : Hydrogels for cell immobilization / Biotech, Bioeng 50 : 357 ~ 364
A.K. Bajpai / 2008 / Responsive polymers in controlled drug delivery / Prog. Polymer Sci 33 : 1088 ~ 1118
C.E. Schante / 2011 / Chemical modifications of hyaluronic acid for the synthesis of derivatives for a broad range of biomedical applications / Carbohydrate Polymer 85 : 469
E.J. Oh / 2008 / Control of the molecular degradation of hyaluronic acid hydrogels for tissue augmentation / J. Biomed. Mater. Res. 86 : 685 ~ 693
A.C. Jen / 1996 / Review : Hydrogels for cell immobilization / Biotech, Bioeng 50 : 357 ~ 364
A.K. Bajpai / 2008 / Responsive polymers in controlled drug delivery / Prog. Polymer Sci 33 : 1088 ~ 1118
C.E. Schante / 2011 / Chemical modifications of hyaluronic acid for the synthesis of derivatives for a broad range of biomedical applications / Carbohydrate Polymer 85 : 469
E.J. Oh / 2008 / Control of the molecular degradation of hyaluronic acid hydrogels for tissue augmentation / J. Biomed. Mater. Res. 86 : 685 ~ 693
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