지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 5 - 11 (7page)
이용수
초록· 키워드
오류제보하기
Background: Topical steroid treatment induces diverse local Wand systemic adverse effects. Several approaches have been tried to reduce the steroid-induced adverse effects. Simultaneous application of physiological lipid mixture is also suggested. Objective: Novel vehicles for topical glucocorticoids formulation were evaluated for the efficacy of reducing side-effects and the drug delivery properties of desonide, a low potency topical steroid. Methods: Transcutaneous permeation and skin residual amount of desonide were measured using Franz diffusion cells. The in vivo anti-inflammatory activity was evaluated using murine model. Results: Topical steroids formulation containing desonide, in either cream or lotion form, were prepared using multi-lamellar emulsion (MLE), and conventional desonide formulations were employed for comparison. MLE formulations did not affect the anti-inflammatory activity of the desonide in phobol ester-induced skin inflammation model, compared with conventional formulations. While the penetrated amounts of desonide were similar for all the tested formulations at 24 hours after application, the increased lag time was observed for the MLE formulations. Interestingly, residual amount of desonide in epidermis was significantly higher in lotion type MLE formulation. Steroid-induced adverse effects, including permeability barrier function impairment, were partially prevented by MLE formulation. Conclusion: Topical desonide formulation using MLE as a vehicle showed a better drug delivery with increased epidermal retention. MLE also partially prevented the steroid-induced side effects, such as skin barrier impairment.
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Aberg KM / 2007 / Psychological stress downregulates epidermal antimicrobial peptide expression and increases severity of cutaneous infections in mice / J Clin Invest 117 :
Ahn SK / 2006 / Effects of a multilamellar emulsion on glucocorticoidinduced epidermal atrophy and barrier impairment / J Dermatol 33 : 80 ~ 90
Elias PM / 2005 / Stratum corneum defensive functions: an integrated view / J Invest Dermatol 125 : 183 ~ 200
Hebert AA / 2007 / Safety and efficacy of desonide hydrogel 0.05% in pediatric subjects with atopic dermatitis / J Drugs Dermatol 6 : 175 ~ 181
Jang BC / 2007 / Dexamethasone suppresses interleukin-1beta-induced human beta-defensin 2 mRNA expression: involvement of p38 MAPK, JNK, MKP-1, and NF-kappaB transcriptional
Ahn SK / 2006 / Effects of a multilamellar emulsion on glucocorticoidinduced epidermal atrophy and barrier impairment / J Dermatol 33 : 80 ~ 90
Elias PM / 2005 / Stratum corneum defensive functions: an integrated view / J Invest Dermatol 125 : 183 ~ 200
Hebert AA / 2007 / Safety and efficacy of desonide hydrogel 0.05% in pediatric subjects with atopic dermatitis / J Drugs Dermatol 6 : 175 ~ 181
Jang BC / 2007 / Dexamethasone suppresses interleukin-1beta-induced human beta-defensin 2 mRNA expression: involvement of p38 MAPK, JNK, MKP-1, and NF-kappaB transcriptional
이 논문의 저자 정보
최근 본 자료
댓글(0)
0