지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 373 - 378 (6page)
이용수
초록· 키워드
오류제보하기
Melasma is a common acquired hyperpigmentary skin disorder characterized by light to dark brown macules and patches occurring in the sun-exposed areas of the face.
Melasma lesional skin is characterized by epidermal hyperpigmentation through increased melanogenesis in epidermal melanocytes. Some patients have dermal melanin but its amount is not significant and its distribution is very heterogeneous in the whole melasma lesional skin. Melasma is not homogeneous disease and there are personal characteristics of patients with melasma. The pathogenesis of melasma is not fully understood, but several hypotheses have been suggested. Increased vascularity in melasma lesions has suggested the role of increased number of enlarged vessels in the development of melasma. Endogeneous and exogeneous stimuli such as sex hormones and ultraviolet irradiation respectively may stimulate the microenvironment leading to the release of various mediators that cause activation of melanocytes and/or these stimuli may directly activate the melanocytes. Melasma patients may have specialized melanocytes with an intrinsic sensitivity to these stimuli. (Ann Dermatol 22(4) 373∼378, 2010)
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Cho SB / 2009 / Melasma treatment in Korean women using a 1064-nm Q-switched Nd:YAG laser with low pulse energy / Clin Exp Dermatol 34 : e847 ~ e850
Grimes PE / 2005 / Light microscopic,immunohistochemical,and ultrastructural alterations in patients with melasma / Am J Dermatopathol 27 : 96 ~ 101
Hernandez-Barrera R / 2008 / Solar elastosis and presence of mast cells as key features in the pathogenesis of melasma / Clin Exp Dermatol 33 : 305 ~ 308
Im S / 2002 / Increased expression of alpha-melanocyte-stimulating hormone in the lesional skin of melasma / Br J Dermatol 146 : 165 ~ 167
Jo HY / 2009 / Co-localization of inducible nitric oxide synthase and phosphorylated Akt in the lesional skins of patients with melasma / J Dermatol 36 : 10 ~ 16
Grimes PE / 2005 / Light microscopic,immunohistochemical,and ultrastructural alterations in patients with melasma / Am J Dermatopathol 27 : 96 ~ 101
Hernandez-Barrera R / 2008 / Solar elastosis and presence of mast cells as key features in the pathogenesis of melasma / Clin Exp Dermatol 33 : 305 ~ 308
Im S / 2002 / Increased expression of alpha-melanocyte-stimulating hormone in the lesional skin of melasma / Br J Dermatol 146 : 165 ~ 167
Jo HY / 2009 / Co-localization of inducible nitric oxide synthase and phosphorylated Akt in the lesional skins of patients with melasma / J Dermatol 36 : 10 ~ 16
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