지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 71 - 75 (5page)
이용수
초록· 키워드
오류제보하기
Rosai-Dorfman disease is a rare, idiopathic, benign, andself-limiting histiocytic proliferative disorder. A 26-year-oldman presented with a single massive cutaneous nodule(reaching 30 cm in diameter) on the left shoulder and back for15 months. The routine hematological and biochemical testswere normal. Magnetic resonance scanning showed the lesioninvolved the skin, subcutaneous tissue, and subjacent musclegroup, accompanied by obvious lymph node enlargement inthe left part of the neck, supraclavicular fossa, and axillaryfossa. The histopathology of the left cervical lymph noderevealed diffuse effacement of the normal nodal architecture,with patchy chronic inflammatory cell infiltrates comprisinglymphocytes and sheets of histiocytes. Some histiocytescontained lymphocytes within their pale cytoplasm. Manymultinucleated giant cells were found; however, caseatinggranulomas were not seen. The skin and muscle biopsyspecimen obtained from the back revealed infiltratinglymphocytes and histiocytes diffusely distributed in thedermis, subcutaneous tissue, and crevices of the muscle fibers.
The phenomenon of emperipolesis and the presence ofmultinucleated giant cells were also seen. Immunohistochemicalstaining revealed that the histiocytes were positivefor S-100 protein and CD68 but negative for CD1a.
Immunophenotyping of the infiltrating lymphocytes indicatedpositive reactions to CD3, CD45RO, CD5, CD7, CD4, CD8(partly), CD79a, CD20 (partly), and Ki-67 (＜1%). The finaldiagnosis was Rosai-Dorfman disease. Owing to the extensiveand deep involvement of the subcutaneous tissue and muscles,the patient did not undergo surgery to excise the massive skinnodule. The lesion showed no obvious change at the 12-monthfollow-up.
목차
등록된 정보가 없습니다.
참고문헌 (9)
참고문헌 신청
Andriko JA / 2001 / Rosai-Dorfman disease isolated to the central nervous system: a report of 11 cases / Mod Pathol 14 : 172 ~ 178
Brenn T / 2002 / Cutaneous rosai-dorfman disease is a distinct clinical entity / Am J Dermatopathol 24 : 385 ~ 391
Fernandopulle SM / 2006 / Rosai-Dorfman disease of the testis: an unusual entity that mimics testicular malignancy / J Clin Pathol 59 : 325 ~ 327
Gupta K / 2011 / Isolated intracranial Rosai-Dorfman disease mimicking meningioma in a child: a case report and review of the literature / Br J Radiol 84 : e138 ~ e141
Henter JI / 2004 / Histiocyte disorders / Crit Rev Oncol Hematol 50 : 157 ~ 174
Brenn T / 2002 / Cutaneous rosai-dorfman disease is a distinct clinical entity / Am J Dermatopathol 24 : 385 ~ 391
Fernandopulle SM / 2006 / Rosai-Dorfman disease of the testis: an unusual entity that mimics testicular malignancy / J Clin Pathol 59 : 325 ~ 327
Gupta K / 2011 / Isolated intracranial Rosai-Dorfman disease mimicking meningioma in a child: a case report and review of the literature / Br J Radiol 84 : e138 ~ e141
Henter JI / 2004 / Histiocyte disorders / Crit Rev Oncol Hematol 50 : 157 ~ 174
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