지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 145 - 149 (5page)
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초록· 키워드
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Background: The etiology of chronic idiopathic urticaria(CIU) is not completely clear, and there are a few antibodiesincluding anti-FcεRI antibody, anti-immunoglobulin E (IgE)antibody, anti-Helicobacter pylori (HP) antibody, and antithyroglobulinantibody (TGAb) that correlate with CIU.
Objective: To investigate the correlation between anti-mastcell antibodies and CIU and to determine which of theseantibodies plays the most important role in CIU pathogenesis.
Methods: A total of 100 patients with CIU, acuteurticaria (AU) patients, and normal controls were included.
The autologous serum skin test (ASST) was performed, andallergen was detected by enzyme-linked immunosorbentassay (ELISA) in each subject. Serum levels of IgE, anti-FcεRIantibody, anti-IgE antibody, anti-HP antibody and TGAbwere measured by ELISA to determine the relevance of theseantibodies with CIU. Results: 1. Food or inhalant allergenswere detected in most AU patients (86%), but no allergenwas detected in CIU patients or in normal controls. 2. Serumanti-FcεRI antibody level was significantly higher in the CIUgroup than that in the AU group (p＜ 0.05) and normal controls(p＜0.05). Serum anti-IgE antibody level was also higher inthe CIU group than that in the AU group (p＜0.05) andnormal controls (p＜0.05). 3. IgE level was lower in the CIUgroup than that in the normal controls (T=190.00, p＜0.05),but IgE level increased in the AU group compared with thatin the normal controls (T=226.00, p＜0.05). 4. The ASSTpositive rates in the CIU and AU groups were 53.4% and12.6% respectively, and ASST was negative in all normalcontrols. The anti-FcεRI antibody level was higher inASST-positive CIU patients than that in ASST-negative CIUpatients (T=101.73, p＜0.05), whereas no anti-IgE antibodydifference was observed between these two groups(T=312.04, p＞0.05). 5. In anti-HP antibody positive andTGAb positive CIU patients, anti-FcεRI antibody positiverate was higher than AU patients (p＜0.01) and normalcontrols (p＜0.01), but no difference were observed inanti-IgE antibody (p＞0.05). Conclusion: CIU is notidiopathic, as most CIU could be defined as autoimmuneurticaria. The anti-FcεRI and anti- IgE antibodies play a keyrole in CIU pathogenesis. Contrary to some previous reports,anti-HP antibody and TGAb have an indirect but not a directcorrelation with CIU.
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참고문헌 (12)
참고문헌 신청
Aamir IS / 2010 / Frequency of autoimmune thyroid disease in chronic urticaria / J Coll Physicians Surg Pak 20 : 158 ~ 161
Bakan EB / 2005 / Lack of correlation between Helicobacter pylori infection and autologous serum skin test in chronic idiopathic urticaria / Int J Dermatol 44 : 993 ~ 995
Belsito DV / 2010 / Second-generation antihistamines for the treatment of chronic idiopathic urticaria / J Drugs Dermatol 9 : 503 ~ 512
Grattan CE / 1986 / A serological mediator in chronic idiopathic urticaria--a clinical, immunological and histological evaluation / Br J Dermatol 114 : 583 ~ 590
Huilan Z / 2010 / Role of the subgroups of T, B, natural killer lymphocyte and serum levels of interleukin-15, interleukin-21 and immunoglobulin E in the pathogenesis of urti
Bakan EB / 2005 / Lack of correlation between Helicobacter pylori infection and autologous serum skin test in chronic idiopathic urticaria / Int J Dermatol 44 : 993 ~ 995
Belsito DV / 2010 / Second-generation antihistamines for the treatment of chronic idiopathic urticaria / J Drugs Dermatol 9 : 503 ~ 512
Grattan CE / 1986 / A serological mediator in chronic idiopathic urticaria--a clinical, immunological and histological evaluation / Br J Dermatol 114 : 583 ~ 590
Huilan Z / 2010 / Role of the subgroups of T, B, natural killer lymphocyte and serum levels of interleukin-15, interleukin-21 and immunoglobulin E in the pathogenesis of urti
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