지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 195 - 202 (8page)
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초록· 키워드
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Background: In the majority of melanomas, the RAS/RAF/MEK/ERK signaling pathway is constitutively activated, dueto oncogenic mutations in the BRAF and NRAS genes. TheBRAF mutation has been mainly described in Caucasianmelanomas. However, there is a lack of study evaluating thestatus, and the clinical significance, of BRAF mutation in theAsian population. Objective: This study was aimed to determinethe frequency of BRAF mutation, and to evaluate thecorrelation of BRAF status with clinicopathologic featuresand outcomes, in Korean primary acral lentiginous melanoma(ALM) patients. Methods: ALM samples (n=36) wereanalyzed for the BRAF V600E mutation, by dual-primingoligonucleotide (DPO) based real-time polymerase chainreaction. The clinicopathologic features and prognosis of thepatients were analyzed with BRAF mutation status. Results:The incidence of BRAF V600E mutation was 19.4% (7/36).
The BRAF V600E mutations were not associated withclinicopathologic features, except for the age factor. All ofthe BRAF-mutant patients survived without recurrence ormetastasis, and have a better clinical outcome than BRAFwild-type patients. Conclusion: In Korean primary ALM, alow frequency of BRAF mutation was shown; and BRAFmutation presented with a favorable prognosis. These resultsindicate that other distinctive genetic mechanisms may havemore important roles in the development and progression ofdisease. Further multicenter study with large sample size isfirmly needed, to confirm the results of our preliminarystudy.
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참고문헌 (25)
참고문헌 신청
Akslen LA / 2005 / BRAF and NRAS mutations are frequent in nodular melanoma but are not associated with tumor cell proliferation or patient survival / J Invest Dermatol 125 :
Ashida A / 2012 / Assessment of BRAF and KIT mutations in Japanese melanoma patients / J Dermatol Sci 66 : 240 ~ 242
Balch CM / 2009 / Final version of 2009 AJCC melanoma staging and classification / J Clin Oncol 27 : 6199 ~ 6206
Bastian BC / 2003 / Classifying melanocytic tumors based on DNA copy number changes / Am J Pathol 163 : 1765 ~ 1770
Bauer J / 2011 / BRAF mutations in cutaneous melanoma are independently associated with age, anatomic site of the primary tumor, and the degree of solar elasto
Ashida A / 2012 / Assessment of BRAF and KIT mutations in Japanese melanoma patients / J Dermatol Sci 66 : 240 ~ 242
Balch CM / 2009 / Final version of 2009 AJCC melanoma staging and classification / J Clin Oncol 27 : 6199 ~ 6206
Bastian BC / 2003 / Classifying melanocytic tumors based on DNA copy number changes / Am J Pathol 163 : 1765 ~ 1770
Bauer J / 2011 / BRAF mutations in cutaneous melanoma are independently associated with age, anatomic site of the primary tumor, and the degree of solar elasto
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