지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 423 - 427 (5page)
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Background: Diabetes is characterized by chronic hyperglycemia,and hyperglycemia can increase reactive oxygen species (ROS) production from the mitochondrial electron transport chain. The formation of ROS in cells induces oxidative stress and activates oxidative damage-inducing genes. There is no research on the protein levels of oxidative damage-related genes AKR1C3 in human diabetic skin. We explored the expression of AKR1C3 in diabetic skin compared with normal skin tissue. Objective: To compare the expression of AKR1C3 in normal skin versus diabetic skin.
Methods: AKR1C3 expression was evaluated by western blotting in 6 diabetic skin tissue samples and 6 normal skin samples. Immunohistochemical staining was carried out to analyze AKR1C3 expression in the 6 diabetic skin tissue samples (July 2009 to December 2011; Department of Plastic and Reconstructive Surgery at Soonchunhyang University Seoul Hospital, Seoul, Korea). Results: The western blotting showed a significant reduction in AKR1C3 protein expression in diabetic skin tissue compared to normal tissue.
Immunohistochemical examination of AKR1C3 showed that it was weakly expressed in all diabetic skin samples.
Conclusion: We believe that AKR1C3 is related to diabetic skin in altered metabolic states which elevate ROS production.
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참고문헌 (26)
참고문헌 신청
Allen RG / 2000 / Oxidative stress and gene regulation / Free Radic Biol Med 28 : 463 ~ 499
Altomare E / 1997 / Oxidative protein damage in human diabetic eye: evidence of a retinal participation / Eur J Cli
Baynes JW / 1991 / Role of oxidative stress in development of complications in diabetes / Diabetes 40 : 405 ~ 412
Bonnefont-Rousselot D / 2000 / Consequences of the diabetic status on the oxidant/antioxidant balance / Diabetes Metab 26 : 163 ~ 176
Brownlee M / 1981 / The biochemistry of the complications of diabetes mellitus / Annu Rev Biochem 50 : 385 ~ 432
Altomare E / 1997 / Oxidative protein damage in human diabetic eye: evidence of a retinal participation / Eur J Cli
Baynes JW / 1991 / Role of oxidative stress in development of complications in diabetes / Diabetes 40 : 405 ~ 412
Bonnefont-Rousselot D / 2000 / Consequences of the diabetic status on the oxidant/antioxidant balance / Diabetes Metab 26 : 163 ~ 176
Brownlee M / 1981 / The biochemistry of the complications of diabetes mellitus / Annu Rev Biochem 50 : 385 ~ 432
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