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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 173 - 178 (6page)
이용수
초록· 키워드
오류제보하기
Background: Topical tacrolimus is an effective anti-inflammatory therapy for acute and chronic states of atopic dermatitis (AD) in both adults and children. Topical tacrolimus has particular use at sensitive areas such as the face, anogenitals, and skin folds of neck and extremities. However, many AD patients also experience aggravated symptoms on trunk. Objective: The aim of this study was to investigate the efficacy and safety of topical tacrolimus for AD patients with truncal lesions. Methods: AD patients with truncal lesions who were aged ≥2 years were recruited from 20 centres in Korea. They received treatment with topical tacrolimus ointment twice daily during 4 weeks. The primary end point was change of the local eczema area and severity index (EASI) of the trunk from baseline to day 28. The secondary end points were changes in the patient global assessment (PGA) score and itch visual analogue scale (VAS) score of the trunk between baseline and day 28. Results: Two hundred and ninety- one patients were recruited, and 176 patients completed the full 4-week treatment course. By the end of the treatment, the mean local EASI of the trunk (2.2±4.71) was significantly decreased from that at baseline (4.71±4.03, p＜0.001). PGA (1.71±1.15) and itch VAS score of the trunk (2.61±2.19) on day 28 were also profoundly decreased compared with the baseline (2.96±1.07 and 5.15±2.47, respectively). No serious adverse events were observed during the study period. Conclusion: Topical tacrolimus is an effective and safe therapy for truncal lesions in AD patients.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Won CH / 2004 / A multicenter trial of the efficacy and safety of 0.03% tacrolimus ointment for atopic dermatitis in Korea / J Dermatolog Treat 15:30~34
Leung DY / 2004 / Disease management of atopic dermatitis: an updated practice parameter. Joint Task Force on Practice Parameters / Ann Allergy Asthma Immunol 93(3 Suppl 2):S1~S21
Eichenfield LF / 2014 / Guidelines of care for the management of atopic dermatitis: section 2. Management and treatment of atopic dermatitis with topical therapies / J Am Acad Dermatol 71:116~132
Reitamo S / 2002 / Efficacy and safety of tacrolimus ointment compared with that of hydrocortisone acetate ointment in children with atopic dermatitis / J Allergy Clin Immunol 109:539~546
Hanifin JM / 1980 / Diagnostic features of atopic dermatitis / Acta Derm Venereol Suppl (Stockh) 92:44~47
Leung DY / 2004 / Disease management of atopic dermatitis: an updated practice parameter. Joint Task Force on Practice Parameters / Ann Allergy Asthma Immunol 93(3 Suppl 2):S1~S21
Eichenfield LF / 2014 / Guidelines of care for the management of atopic dermatitis: section 2. Management and treatment of atopic dermatitis with topical therapies / J Am Acad Dermatol 71:116~132
Reitamo S / 2002 / Efficacy and safety of tacrolimus ointment compared with that of hydrocortisone acetate ointment in children with atopic dermatitis / J Allergy Clin Immunol 109:539~546
Hanifin JM / 1980 / Diagnostic features of atopic dermatitis / Acta Derm Venereol Suppl (Stockh) 92:44~47
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