지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 364 - 370 (7page)
이용수
초록· 키워드
오류제보하기
Background: Chronic hand eczema (CHE) tends to be refractory to conventional therapy. Previous clinical trials have found that a 24-week treatment course of oral alitretinoin is effective and well tolerated for CHE treatment. Objective: The aim of this study was to investigate the efficacy and safety of oral alitretinoin in Korean CHE patients. Methods: A total of 27 patients with moderate to severe CHE took 30 mg of alitretinoin daily for 12 weeks. The primary efficacy parameter was the physician’s global assessment (PGA). The response was defined as a patient being “clear” or “almost clear” of disease. The secondary efficacy parameters were the modified total lesion symptom score (mTLSS) and the patients’ global assessment (PaGA). All adverse events and laboratory abnormalities were recorded during the treatment period.
Results: Alitretinoin led to CHE symptom improvement in 44.4% of patients. The PGA, mTLSS, and PaGA scores correlated well with each other. Reported adverse events were typical retinoid class effects and headache was the most common. Conclusion: Taking 30 mg of oral alitretinoin daily for 12 weeks was found to be effective in treating Korean patients with CHE, compared with the 24 week-treatment shown in previous studies.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Diepgen TL. / 2007 / Management of chronic hand eczema / Contact Dermatitis 57:203~210
Diepgen TL. / 2012 / Efficacy and tolerability of alitretinoin for chronic hand eczema under daily practice conditions : results of the TOCCATA open study comprising 680 patients / Acta Derm Venereol 92:251~255
Landow K. / 1998 / Hand dermatitis. The perennial scourge / Postgrad Med 103:141~152
Ruzicka T. / 2004 / Oral alitretinoin(9-cis-retinoic acid)therapy for chronic hand dermatitis in patients refractory to standard therapy : results of a randomized, double-blind, placebo-controlled, multicenter trial / Arch Dermatol 140:1453~1459
Ruzicka T. / 2008 / Efficacy and safety of oral alitretinoin(9-cis retinoic acid)in patients with severe chronic hand eczema refractory to topical corticosteroids : results of a randomized, double-blind, placebo-controlled, multicentre trial / Br J Dermatol 158:808~817
Diepgen TL. / 2012 / Efficacy and tolerability of alitretinoin for chronic hand eczema under daily practice conditions : results of the TOCCATA open study comprising 680 patients / Acta Derm Venereol 92:251~255
Landow K. / 1998 / Hand dermatitis. The perennial scourge / Postgrad Med 103:141~152
Ruzicka T. / 2004 / Oral alitretinoin(9-cis-retinoic acid)therapy for chronic hand dermatitis in patients refractory to standard therapy : results of a randomized, double-blind, placebo-controlled, multicenter trial / Arch Dermatol 140:1453~1459
Ruzicka T. / 2008 / Efficacy and safety of oral alitretinoin(9-cis retinoic acid)in patients with severe chronic hand eczema refractory to topical corticosteroids : results of a randomized, double-blind, placebo-controlled, multicentre trial / Br J Dermatol 158:808~817
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