지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 192 - 198 (7page)
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초록· 키워드
오류제보하기
Background: Although the therapeutic mechanism of balneotherapy for atopic dermatitis has not been clarified, many atopic patients who visit thermomineral springs have shown clinical improvements. Objective: This study was aimed to evaluate the immunomodulatory effect of thermomineral water balneotherapy on the atopic dermatitis murine model.
Methods: The oxazolone-induced atopic dermatitis murine model was used to evaluate the therapeutic effect of balneotherapy with Deokgu thermomineral water compared with distilled water. Histologic evaluation and confocal microscopic imaging were performed to analyze the lesional expression of cluster-of-differentiation (CD)4 and forkhead box p3 (Foxp3). Lesional mRNA expression of interleukin (IL) 33, thymic stromal lymphopoietin (TSLP), and Foxp3 was evaluated by real-time reverse transcription polymerase chain reaction. Results: Compared with the distilled water bath group, confocal microscopic evaluation of CD4 and Foxp3 merged images showed increased expression of regulatory T cells in the thermomineral balneotherapy group. The lesional mRNA level of IL-33 showed a reduced trend in the thermomineral balneotherapy group, whereas the level of mRNA of Foxp3 was increased. TSLP showed a decreased trend in both distilled water and thermomineral water bath groups. There was a trend of reduced expression in lesional IL-33 mRNA but increased cell count of CD4+ Foxp3+ regulatory T cells in thermomineral balneotherapy compared with distilled water bath. Conclusion: Therefore, thermomineral balneotherapy can be an effective and safe adjuvant therapeutic option for atopic dermatitis.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Hann SK / 1996 / Mineral water and spas in Korea / Clin Dermatol 14:633~635
Kim JW / 2012 / Therapeutic effectiveness and its underlying immunologic mechanisms of Korean hot spring water on atopic dermatitis / J Korean Acad Hot Spring 1:48~54
Cozzi F. / 1995 / Hypothalamic-pituitary-adrenal axis dysregulation in healthy subjects undergoing mud-bath applications / Arthritis Rheum 38:724~726
Kubota K. / 1997 / Treatment of refractory cases of atopic dermatitis with acidic hot-spring bathing / Acta Derm Venereol 77:452~454
Inoue T. / 1999 / Bactericidal activity of manganese and iodide ions against Staphylococcus aureus : a possible treatment for acute atopic dermatitis / Acta Derm Venereol 79:360~362
Kim JW / 2012 / Therapeutic effectiveness and its underlying immunologic mechanisms of Korean hot spring water on atopic dermatitis / J Korean Acad Hot Spring 1:48~54
Cozzi F. / 1995 / Hypothalamic-pituitary-adrenal axis dysregulation in healthy subjects undergoing mud-bath applications / Arthritis Rheum 38:724~726
Kubota K. / 1997 / Treatment of refractory cases of atopic dermatitis with acidic hot-spring bathing / Acta Derm Venereol 77:452~454
Inoue T. / 1999 / Bactericidal activity of manganese and iodide ions against Staphylococcus aureus : a possible treatment for acute atopic dermatitis / Acta Derm Venereol 79:360~362
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