지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 178 - 183 (6page)
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초록· 키워드
오류제보하기
Background: Vitiligo is a chronic, common disease of unknownetiology, and oxidative stress is suggested to have arole in its etiopathogenesis. Objective: Advanced oxidationprotein products (AOPPs), prooxidant-antioxidant balance(PAB), and ferric-reducing antioxidant power (FRAP) wereevaluated regarding their role in the pathogenesis of vitiligoas well as their relationship with clinical presentation anddisease severity, and these parameters were compared withthose of healthy controls. Methods: The study included 53patients with vitiligo and 20 healthy volunteers as the controlgroup. AOPP level, PAB, and FRAP were determined by colorimetricmethods. Results: PAB and FRAP level were significantlyhigher in patients with vitiligo than in healthy controls(p＜0.001). The AOPP levels in vitiligo patients werenot statistically significantly higher than those in healthycontrols. The Vitiligo Area Scoring Index positively correlatedwith disease duration (rs: 0.531, p＜0.001). Conclusion:To the best of our knowledge, this is the first report of AOPPand PAB status in vitiligo. PAB may be used as an indicatorfor oxidative stress in the etiopathogenesis of vitiligo. Our resultsshow that these parameters may play a major role in themelanocyte damage observed in vitiligo. Further studies arerequired to confirm the mechanisms underlying this effect.
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참고문헌 (22)
참고문헌 신청
Akoglu G / 2013 / Evaluation of total oxidant and antioxidant status in localized and generalized vitiligo / Clin Exp Dermatol 38 : 701 ~ 706
Alamdari DH / 2008 / Prooxidant-antioxidant balance as a new risk factor in patients with angiographically defined coronary artery disease / Clin Biochem 41 : 375 ~ 380
Arican O / 2008 / Oxidative stress in the blood of patients with active localized vitiligo / Acta Dermatovenerol Alp Pannonica Adriat 17 : 12 ~ 16
Benzie IF / 1996 / The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay / Anal Biochem 239 : 70 ~ 76
Boisseau-Garsaud AM / 2002 / rIncrease in total blood antioxidant status and selenium levels in black patients with active vitiligo / Int J Dermatol 41 : 640 ~ 642
Alamdari DH / 2008 / Prooxidant-antioxidant balance as a new risk factor in patients with angiographically defined coronary artery disease / Clin Biochem 41 : 375 ~ 380
Arican O / 2008 / Oxidative stress in the blood of patients with active localized vitiligo / Acta Dermatovenerol Alp Pannonica Adriat 17 : 12 ~ 16
Benzie IF / 1996 / The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay / Anal Biochem 239 : 70 ~ 76
Boisseau-Garsaud AM / 2002 / rIncrease in total blood antioxidant status and selenium levels in black patients with active vitiligo / Int J Dermatol 41 : 640 ~ 642
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