지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 121 - 127 (7page)
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초록· 키워드
오류제보하기
Background: Psoriasis is an autoimmune disease that iscaused by a shift in the Th1/Th2 balance toward Th1-dominant immunity. It has been established as an effectivetreatment to counteract psoriasis by subcutaneous injectionof recombinant interleukin (IL)-4, and IL-4 gene therapy bytopical transdermal penetration has shown its antipsoriaticeffect in mice. Retinoic acid (RA) and dimethylsulfoxide canincrease the efficiency of gene transfection in the topicaltransdermal delivery system. Objective: We investigatedwhether RA could improve anti-psoriasis efficiency usingIL-4 expression plasmid pORF-mIL-4 (pIL-4) via transdermaldelivery system in K14-vascular endothelial growth (K14-VEGF) factor transgenic mice. Methods: After pretreatmentwith RA, plasmid pIL-4 in 10% dimethylsulfoxide wasapplied to the ear skin by topical transdermal penetration.
Hematoxylin- eosin staining and immunohistochemistrywere performed with ear samples to evaluate anti-psoriasisefficiency in mice. Results: The psoriasis pathologicalfeatures were relieved and psoriasis-associated factors weresignificantly reduced. Conclusion: Our results reveal thattopical application of pIL-4 in dimethylsulfoxide by transdermaldelivery with RA pretreatment can improve psoriasissignificantly.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Baker BS / 1992 / Is epidermal cell proliferation in psoriatic skin grafts on nude mice driven by T-cell derived cytokines? / Br J Dermatol 126 : 105 ~ 110
Boniface K / 2005 / Keratinocytes as targets for interleukin-10-related cytokines: a putative role in the pathogenesis of psoriasis / Eur Cytokine Netw 16 : 309 ~ 319
Catalina MD / 1999 / Selective requirements for leukocyte adhesion molecules in models of acute and chronic cutaneous inflammation: participation of E- and P- but not L-sele
Chen Q / 2004 / Retinoic acid regulates cell cycle progression and cell differentiation in human monocytic THP-1 cells / Exp Cell Res 297 : 68 ~ 81
Chen X / 2010 / Retinoic acid and dimethyl sulfoxide promote efficient delivery of transgenes to mouse skin by topically transdermal penetration / Drug Deliv 17 : 385 ~ 390
Boniface K / 2005 / Keratinocytes as targets for interleukin-10-related cytokines: a putative role in the pathogenesis of psoriasis / Eur Cytokine Netw 16 : 309 ~ 319
Catalina MD / 1999 / Selective requirements for leukocyte adhesion molecules in models of acute and chronic cutaneous inflammation: participation of E- and P- but not L-sele
Chen Q / 2004 / Retinoic acid regulates cell cycle progression and cell differentiation in human monocytic THP-1 cells / Exp Cell Res 297 : 68 ~ 81
Chen X / 2010 / Retinoic acid and dimethyl sulfoxide promote efficient delivery of transgenes to mouse skin by topically transdermal penetration / Drug Deliv 17 : 385 ~ 390
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