지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 237 - 242 (6page)
이용수
초록· 키워드
오류제보하기
Background: Psoriasis is a chronic inflammatory skin disease
that affects approximately 1~3% of the general population.
Objective: We performed cDNA microarray analysis with
using the dendrimer labelling method to investigate the gene
expression profile in the peripheral blood mononuclear cells
(PBMCs) of psoriatic patients. Methods: The peripheral
blood mononuclear cells of 5 patients with psoriasis and 8
control subjects were used in the gene expression analyses
of psoriasis. Results: We identified 212 differentially expressed
genes that showed at least a two-fold induction
and/or reduction in psoriatic patients. Among those, 63
genes, including CD44, CD56 and IL7R, were induced,
while 139 genes, including the sphingosine kinase 1 and
p16-INK genes, were reduced in the psoriatic patients.
Conclusion: We can speculate that these genes may have a
role for the pathogenesis of psoriasis via their affecting
different cellular functions. Our results suggest a possible
mechanism by which activated immune cells migrate from
the blood to the skin in psoriatic patients, and we provide
novel putative targets for developing drugs to treat psoriasis.
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Asadullah K / 2002 / Novel immunotherapies for psoriasis / Trends Immunol 23 : 47 ~ 53
Boehncke WH / 1997 / Induction of psoriasiform inflammation by a bacterial superantigen in the SCID-hu xenogeneic transplantation model / J Cutan Pathol 24 : 1 ~ 7
Bos JD / 1999 / The pathogenesis of psoriasis: immunological facts and speculations / Immunol Today 20 : 40 ~ 46
Carafoli F / 2008 / Structure of the tandem fibronectin type 3 domains of neural cell adhesion molecule / J Mol Biol 377 : 524 ~ 534
Golshani R / 2008 / Hyaluronic acid synthase-1 expression regulates bladder cancer growth, invasion, and angiogenesis through CD44 / Cancer Res 68 : 483 ~ 491
Boehncke WH / 1997 / Induction of psoriasiform inflammation by a bacterial superantigen in the SCID-hu xenogeneic transplantation model / J Cutan Pathol 24 : 1 ~ 7
Bos JD / 1999 / The pathogenesis of psoriasis: immunological facts and speculations / Immunol Today 20 : 40 ~ 46
Carafoli F / 2008 / Structure of the tandem fibronectin type 3 domains of neural cell adhesion molecule / J Mol Biol 377 : 524 ~ 534
Golshani R / 2008 / Hyaluronic acid synthase-1 expression regulates bladder cancer growth, invasion, and angiogenesis through CD44 / Cancer Res 68 : 483 ~ 491
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