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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 653 - 661 (9page)
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이 논문의 연구 히스토리 (2)
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Background: Citron is well known for an abundance of antioxidative and anti-inflammatory ingredients such as vitamin C, polyphenol compounds, flavonoids, and limonoids. Objective: In this study, we aimed to evaluate the effects of citron essential oils on rosacea mediators in activated keratinocytes in vitro. Methods: Normal human epidermal keratinocytes (NHEKs) were stimulated with 1α, 25-dihydroxyvitamin D3 (VD3) and interleukin 33 (IL-33) with LL-37 to induce rosacea mediators such as kallikrein 5 (KLK5), cathelicidin, vascular endothelial growth factor (VEGF), and transient receptor potential vanilloid 1 (TRPV1). These mediators were analyzed by performing reverse-transcription polymerase chain reaction (PCR), quantitative real-time PCR, immunocytofluorescence and enzyme-linked immunosorbent assay after NHEKs were treated with citron seed and unripe citron essential oils. Results: The messenger RNA (mRNA) and protein levels of KLK5 and LL-37 induced by VD3 were suppressed by citron seed and unripe citron essential oils. Furthermore, the mRNA and protein levels of VEGF and TRPV1 induced by IL-33 with LL-37 were also suppressed by citron essential oils. Conclusion: These results show that citron essential oils have suppressive effects on rosacea mediators in activated epidermal keratinocytes, which indicates that the citron essential oils may be valuable adjuvant therapeutic agents for rosacea.
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참고문헌 (41)
참고문헌 신청
Sawamura M / 2005 / Inhibitory effect of yuzu essential oil on the formation of N-nitrosodimethylamine in vegetables / J Agric Food Chem 53:4281~4287
Yoo KM / 2004 / Variation in major antioxidants and total antioxidant activity of Yuzu (Citrus junos Sieb ex Tanaka) during maturation and between cultivars / J Agric Food Chem 52:5907~5913
Zou Z / 2016 / Antioxidant activity of citrus fruits / Food Chem 196:885~896
Hirota R / 2010 / Anti‐inflammatory Effects of limonene from yuzu (Citrus junos Tanaka) essential oil on eosinophils / J Food Sci 75:H87~H92
Crawford GH / 2004 / Rosacea: I. Etiology, pathogenesis, and subtype classification / J Am Acad Dermatol 51:327~341
Yoo KM / 2004 / Variation in major antioxidants and total antioxidant activity of Yuzu (Citrus junos Sieb ex Tanaka) during maturation and between cultivars / J Agric Food Chem 52:5907~5913
Zou Z / 2016 / Antioxidant activity of citrus fruits / Food Chem 196:885~896
Hirota R / 2010 / Anti‐inflammatory Effects of limonene from yuzu (Citrus junos Tanaka) essential oil on eosinophils / J Food Sci 75:H87~H92
Crawford GH / 2004 / Rosacea: I. Etiology, pathogenesis, and subtype classification / J Am Acad Dermatol 51:327~341
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