지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 8 - 12 (5page)
이용수
초록· 키워드
오류제보하기
Background: Bullous pemphigoid (BP) is an autoimmune disease with bullous vesicles and an incidence of 0.2 to 1.4 per 100,000 inhabitants. Many studies have been published demonstrating the association of pemphigoid with HLA class II system alleles in different populations, however there are no data on the BP, one of the most heterogeneous in the world. Objective: To typify HLA alleles in Brazilians with Bullous pemphigoid. Methods: The study group included 17 Brazilian patients with a confirmed diagnosis of BP from a hospital in Sao Paulo city, southeast Brazil. DNA was extracted from peripheral blood using Qiagen kits and HLA A, B, C, DR and DQ typing was performed using polymerase chain reaction. The control group was composed of a database of 297 deceased donors from the city of Sao Paulo. The statistical significance level was adjusted using the Bonferroni correction depending on the phenotypic frequencies evaluated for HLA class I (A, B and C) and class II (DRB1, DQB1 and DQA1). Results: Our findings show that alleles HLA C*17, DQB1*03:01, DQA1*01:03 and DQA1*05:05 are associated with the onset of the disease in the Brazilian population, with relative risks of 8.31 (2.46 to 28.16), 3.76 (1.81 to 7.79), 3.57 (1.53 to 8.33), and 4.02 (1.87 to 8.64), respectively (p＜0.005). Conclusion: Our data indicate that Brazilian patients with BP present the same genetic predisposition linked to HLA-DQB1*03:01 previously reported in Caucasian and Iranian individuals and our study introduces three new alleles (C*17, DQA1*01:03 and DQA1*05:05) involved in the pathophysiology of BP.
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Walsh SR / 2005 / Bullous pemphigoid: from bench to bedside / Drugs 65:905~926
Bernard P / 1995 / Incidence and distribution of subepidermal autoimmune bullous skin diseases in three French regions. Bullous Diseases French Study Group / Arch Dermatol 131:48~52
Langan SM / 2008 / Bullous pemphigoid and pemphigus vulgaris--incidence and mortality in the UK: population based cohort study / BMJ 337:a180
Gudi VS / 2005 / Annual incidence and mortality of bullous pemphigoid in the Grampian Region of North-east Scotland / Br J Dermatol 153:424~427
Stanley JR / 1981 / Characterization of bullous pemphigoid antigen: a unique basement membrane protein of stratified squamous epithelia / Cell 24:897~903
Bernard P / 1995 / Incidence and distribution of subepidermal autoimmune bullous skin diseases in three French regions. Bullous Diseases French Study Group / Arch Dermatol 131:48~52
Langan SM / 2008 / Bullous pemphigoid and pemphigus vulgaris--incidence and mortality in the UK: population based cohort study / BMJ 337:a180
Gudi VS / 2005 / Annual incidence and mortality of bullous pemphigoid in the Grampian Region of North-east Scotland / Br J Dermatol 153:424~427
Stanley JR / 1981 / Characterization of bullous pemphigoid antigen: a unique basement membrane protein of stratified squamous epithelia / Cell 24:897~903
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