지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 733 - 738 (6page)
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초록· 키워드
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Background: Scalp seborrheic dermatitis is a chronic type ofinflammatory dermatosis that is associated with sebumsecretion and proliferation of Malassezia species. Ketoconazoleor zinc-pyrithione shampoos are common treatmentsfor scalp seborrheic dermatitis. However, shampoos comprisingdifferent compounds are required to provide patientswith a wider range of treatment options. Objective: Thisstudy was designed to evaluate a new-formula shampoo thatcontains natural ingredients-including extract of Rosacentifolia petals and epigallocatechin gallate (EGCG)-thatexert antioxidative, anti-inflammatory, and sebum secretioninhibitory effects, and antifungal agents for the treatment ofscalp seborrheic dermatitis. Methods: Seventy-five patientswere randomized into three treatment groups; new-formulashampoo, 2% ketoconazole shampoo, and 1% zinc- pyrithioneshampoo. The clinical severity scores and sebumlevels were assessed by the same dermatologists at baseline(week 0), and at 2 and 4 weeks after using the shampoo. Usersatisfaction and irritation were also assessed with the aid ofa questionnaire. Results: The efficacy of the new-formulashampoo was comparable to that of both the 1% zincpyrithioneshampoo and the 2% ketoconazole shampoo.
Furthermore, it was found to provide a more rapid responsethan the 1% zinc-pyrithione shampoo for mild erythemalesions and was associated with greater user satisfactioncompared with the 2% ketoconazole shampoo. However,the new-formula shampoo did not exhibit the previouslyreported sebum inhibitory effect. Conclusion: Extract of R.
centifolia petals or EGCG could be useful ingredients in thetreatment of scalp seborrheic dermatitis.
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참고문헌 (16)
참고문헌 신청
Andersson DA / 2009 / Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn2+ / Proc Natl Acad Sci U S A 106 : 8374 ~ 8379
Baroni A / 2006 / Toll-like receptor 2 (TLR2) mediates intracellular signalling in human keratinocytes in response to Malassezia furfur / Arch Dermatol Res 297 : 280 ~ 288
Como JA / 1994 / Oral azole drugs as systemic antifungal therapy / N Engl J Med 330 : 263 ~ 272
De Luca C / 2010 / Surface lipids as multifunctional mediators of skin responses to environmental stimuli / Mediators Inflamm 2010 : 321494 ~
DeAngelis YM / 2005 / Three etiologic facets of dandruff and seborrheic dermatitis: Malassezia fungi, sebaceous lipids, and individual sensitivity / J Investig Dermatol Symp
Baroni A / 2006 / Toll-like receptor 2 (TLR2) mediates intracellular signalling in human keratinocytes in response to Malassezia furfur / Arch Dermatol Res 297 : 280 ~ 288
Como JA / 1994 / Oral azole drugs as systemic antifungal therapy / N Engl J Med 330 : 263 ~ 272
De Luca C / 2010 / Surface lipids as multifunctional mediators of skin responses to environmental stimuli / Mediators Inflamm 2010 : 321494 ~
DeAngelis YM / 2005 / Three etiologic facets of dandruff and seborrheic dermatitis: Malassezia fungi, sebaceous lipids, and individual sensitivity / J Investig Dermatol Symp
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