지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 61 - 65 (5page)
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초록· 키워드
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Background: Alopecia areata is marked by autoimmune assault on the hair follicle resulting in hair loss. T helper 17cell subset has important roles in protecting the host against extracellular pathogens, however, also promotes inflammatory pathology in autoimmune disease, and it expresses both interleukin (IL)-17A and IL-17F, which can signal via the IL-17 receptor A. Objective: To investigate the significance of IL17A and IL17RA gene polymorphisms in the susceptibility to alopecia areata. Methods: We conducted case-control association study of 238 alopecia areata patients and 270matched healthy controls. Allele frequency of total 2 single nucleotide polymorphims in the IL17A gene and 4 single nucleotide polymorphims in the IL17RA gene were studied.
The statistical analyses were performed according to onset age, the presence of familyhistory, clinical subtypes, and presence of nail involvement or body hair involvement.
Results: One single nucleotide polymorphim (rs879577) of IL17RA gene showed significant difference between alopecia areata patients group and controls group (p=0.0288). One single nucleotide polymorphim (rs4819554)of IL17RA gene showed significant difference between the early onset and late onset alopecia areata (p=0.0421).
Conclusion: IL17RA gene polymorphism might contribute to the increased susceptibility to alopecia areata in Korean population, and IL17RA gene polymorphism may be associated with onset age.
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참고문헌 (25)
참고문헌 신청
Aggarwal S / 2003 / Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17 / J Biol Chem 278 : 1910 ~ 1914
Alkhalifah A / 2010 / Alopecia areata update: part I. Clinical picture, histopathology, and pathogenesis / J Am Acad Dermatol 62 : 177 ~ 188
Barrett JC / 2005 / Haploview: analysis and visualization of LD and haplotype maps / Bioinformatics 21 : 263 ~ 265
Bettelli E / 2006 / Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells / Nature 441 : 235 ~ 238
Ghilardi N / 2007 / Targeting the development and effector functions of TH17 cells / Semin Immunol 19 : 383 ~ 393
Alkhalifah A / 2010 / Alopecia areata update: part I. Clinical picture, histopathology, and pathogenesis / J Am Acad Dermatol 62 : 177 ~ 188
Barrett JC / 2005 / Haploview: analysis and visualization of LD and haplotype maps / Bioinformatics 21 : 263 ~ 265
Bettelli E / 2006 / Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells / Nature 441 : 235 ~ 238
Ghilardi N / 2007 / Targeting the development and effector functions of TH17 cells / Semin Immunol 19 : 383 ~ 393
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