지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 144 - 149 (6page)
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초록· 키워드
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Background: Bacteria associated with marine invertebrates are a rich source of bioactive metabolites. Objective: The effects of marine bacteria extracts on pigmentation were investigated to find novel whitening agents. Methods: The marine bacteria collected near Gangwha Island in Korea were isolated and extracted using organic solvent. The organic extracts were screened and selected using the cell free tyrosinase activity. The whitening effects of the selected extract were further investigated using cultured melanocytes,cultured skin and in vivo zebrafish. The whitening mechanism of the marine extract was also investigated.
Results: The marine bacterial methylene chloride extract reduced the pigmentation of Melan-a cells, human melanocytes, cultured skin and in vivo zebrafish. The decrease in pigmentation was due to the inhibition of tyrosinase activity and the expression of tyrosinase and microphthalmia-associated transcription factor protein.
These bacteria were identified as a novel Pseudomonas species. Conclusion: The methylene chloride extract of marine pseudomonas species possesses a whitening effect.
Further chemical isolation and characterization of the active compounds from this marine bacterial extract are needed.
(Ann Dermatol 23(2) 144∼149, 2011)
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참고문헌 (7)
참고문헌 신청
Bertolotto C / 1998 / Different cis-acting elements are involved in the regulation of TRP1 and TRP2 promoter activities by cyclic AMP: pivotal role of M boxes (GTCATGTGCT) an
Choi TY / 2007 / Zebrafish as a new model for phenotype-based screening of melanogenic regulatory compounds / Pigment Cell Res 20 : 120 ~ 127
Faulkner DJ / 2002 / Marine natural products / Nat Prod Rep 19 : 1 ~ 48
Jimbow K / 1974 / Mechanism of depigmentation by hydroquinone / J Invest Dermatol 62 : 436 ~ 449
Proksch P / 2002 / Drugs from the seas - current status and microbiological implications / Appl Microbiol Biotechnol 59 : 125 ~ 134
Choi TY / 2007 / Zebrafish as a new model for phenotype-based screening of melanogenic regulatory compounds / Pigment Cell Res 20 : 120 ~ 127
Faulkner DJ / 2002 / Marine natural products / Nat Prod Rep 19 : 1 ~ 48
Jimbow K / 1974 / Mechanism of depigmentation by hydroquinone / J Invest Dermatol 62 : 436 ~ 449
Proksch P / 2002 / Drugs from the seas - current status and microbiological implications / Appl Microbiol Biotechnol 59 : 125 ~ 134
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