지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 138 - 143 (6page)
이용수
초록· 키워드
오류제보하기
Background: β-catenin plays a pivotal role in hair follicle development and hair growth cycle. Objective: The aim of this study was to identify β-catenin-regulated genes in cultured human hair outer root sheath (ORS) cells. Methods:Primary cultured ORS cells were transduced with recombinant adenovirus expressing N-terminal truncated β-catenin (constitutive active form), and β-catenin-regulated genes were identified. Results: Overexpression of the constitutively active form of β-catenin led to induction of Sox9 expression at both mRNA and protein levels. To investigate the potential role of Sox9, we made the recombinant adenovirus expressing green fluorescent protein-tagged Sox9, and then transduced into cultured ORS cells. Interestingly, Sox9 induced the expression of keratin 15, increased the proliferation of ORS cells in vitro, and enhanced colony-forming activity. Conclusion: Our results suggest that Sox9 is a β-catenin-regulated gene in ORS cells,and has potential importance in the regulation of hair follicle homeostasis.(Ann Dermatol 23(2) 138∼143, 2011)
목차
등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
Barrionuevo F / 2010 / SOX E genes: SOX9 and SOX8 in mammalian testis development / Int J Biochem Cell Biol 42 : 433 ~ 436
Blache P / 2004 / SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes / J Cell Biol 166 : 37 ~ 47
Claudinot S / 2005 / Long-term renewal of hair follicles from clonogenic multipotent stem cells / Proc Natl Acad Sci U S A 102 : 14677 ~ 14682
Cotsarelis G / 1990 / Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis / Cel
Gat U / 1998 / De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated β-catenin in skin / Cell 95 : 605 ~ 614
Blache P / 2004 / SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes / J Cell Biol 166 : 37 ~ 47
Claudinot S / 2005 / Long-term renewal of hair follicles from clonogenic multipotent stem cells / Proc Natl Acad Sci U S A 102 : 14677 ~ 14682
Cotsarelis G / 1990 / Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis / Cel
Gat U / 1998 / De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated β-catenin in skin / Cell 95 : 605 ~ 614
이 논문의 저자 정보
최근 본 자료
댓글(0)
0