지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 290 - 299 (10page)
이용수
초록· 키워드
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Background: ‘Retinoid dermatitis’ is a retinoid-induced irritant contact dermatitis (ICD). The mechanism of retinoid dermatitis may be different from that of other ICDs.
However, it remains uncertain how topical retinoid induce ICD. Objective: We compared several aspects of contact dermatitis induced by topical retinol and benzalkonium chloride (BKC) on hairless mice skin. Methods: 2% retinol or 2.5% BKC was applied to hairless mice and transepidermal water loss (TEWL), ear thickness, histologic and immunohistochemical findings were compared. We also compared mRNA expression of inflammatory cytokines, epidermal differential markers, cyclooxygenases (COXs) and heparin binding epidermal growth factor like growth factor (HBEGF).
Results: Topical application of 2% retinol and 2.5%BKC increased TEWL and ear thickness in similar intensity.
Epidermal hyperplasia was more prominent in retinol treated skin. Proliferating cell nuclear antigen, involucrin and loricrin expression were higher in retinol-treated skin than in BKC-treated skin. Filaggrin, however, was more expressed in BKC-treated skin. The mRNA expression of IL-8, TNF-α,COX-2, involucrin, loricrin and filaggrin were increased in both retinol- and BKC-treated skin in similar intensity.
HB-EGF was more significantly increased in retinol-treated skin. Conclusion: Elevated HB-EGF and epidermal hyperplasia are more prominent features of retinoid dermatitis than in BKC-induced ICD.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Ale SI / 1997 / Differential irritant skin responses to tandem application of topical retinoic acid and sodium lauryl sulphate:II.Effect of time between first and second expo
Berardesca E / 1995 / Mechanisms of skin irritations / Curr Probl Dermatol 23 : 1 ~ 8
Chapellier B / 2002 / Physiological and retinoid-induced proliferations of epidermis basal keratinocytes are differently controlled / EMBO J 21 : 3402 ~ 3413
Chen S / 1995 / Retinoic acid receptor gamma mediates topical retinoid efficacy and irritation in animal models / J Invest Dermatol 104 : 779 ~ 783
Coquette A / 2003 / Analysis of interleukin-1alpha(IL-1alpha)and interleukin-8(IL-8)expression and release in in vitro reconstructed human epidermis for the prediction of in
Berardesca E / 1995 / Mechanisms of skin irritations / Curr Probl Dermatol 23 : 1 ~ 8
Chapellier B / 2002 / Physiological and retinoid-induced proliferations of epidermis basal keratinocytes are differently controlled / EMBO J 21 : 3402 ~ 3413
Chen S / 1995 / Retinoic acid receptor gamma mediates topical retinoid efficacy and irritation in animal models / J Invest Dermatol 104 : 779 ~ 783
Coquette A / 2003 / Analysis of interleukin-1alpha(IL-1alpha)and interleukin-8(IL-8)expression and release in in vitro reconstructed human epidermis for the prediction of in
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