지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 40 - 47 (8page)
이용수
초록· 키워드
오류제보하기
Background: Neuropathic pain, including paresthesia/dysesthesia in the lower extremities, always develops and remains for at least one month, to variable degrees, after percutaneous endoscopic lumbar discectomy (PELD). The recently discovered dual analgesic mechanisms of action, similar to those of antidepressants and anticonvulsants, enable nefopam (NFP) to treat neuropathic pain. This study was performed to determine whether NFP might reduce the neuropathic pain component of postoperative pain.Methods: Eighty patients, who underwent PELD due to herniated nucleus pulposus (HNP) at L4-L5, were randomly divided into two equal groups, one receiving NFP (with a mixture of morphine and ketorolac) and the other normal saline (NS) with the same mixture. The number of bolus infusions and the infused volume for 3 days were compared in both groups. The adverse reactions (ADRs) in both groups were recorded and compared. The neuropathic pain symptom inventory (NPSI) score was compared in both groups on postoperative days 1, 3, 7, 30, 60, and 90.Results: The mean attempted number of bolus infusions, and effective infused bolus volume for 3 days was lower in the NFP group for 3 days. The most commonly reported ADRs were nausea, dizziness, and somnolence, in order of frequency in the NFP group. The median NPSI score, and all 5 median sub-scores in the NFP group, were significantly lower than that of the NS group until postoperative day 30. Conclusions: NFP significantly reduced the neuropathic pain component, including paresthesia/dysesthesia until 1 month after PELD. The common ADRs were nausea, dizziness, somnolence, and ataxia. (Korean J Pain 2016; 29: 40-47)
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
김경훈 / 2011 / Use of Lidocaine Patch for Percutaneous Endoscopic Lumbar Discectomy / The Korean Journal of Pain 24(2):74~80
Cho JY / 2011 / Prevention of development of postoperative dysesthesia in transforaminal percutaneous endoscopic lumbar discectomy for intracanalicular lumbar disc herniation : floating retraction technique / Minim Invasive Neurosurg 54:214~218
Loeser JD / 2001 / Bonica's management of pain / Lippincott Williams & Wilkins :1565~1578
Gregori-Puigjané E / 2012 / Identifying mechanism-of-action targets for drugs and probes / Proc Natl Acad Sci U S A 109:11178~11183
Moore RA / 2011 / Single dose oral analgesics for acute postoperative pain in adults / Cochrane Database Syst Rev :CD008659
Cho JY / 2011 / Prevention of development of postoperative dysesthesia in transforaminal percutaneous endoscopic lumbar discectomy for intracanalicular lumbar disc herniation : floating retraction technique / Minim Invasive Neurosurg 54:214~218
Loeser JD / 2001 / Bonica's management of pain / Lippincott Williams & Wilkins :1565~1578
Gregori-Puigjané E / 2012 / Identifying mechanism-of-action targets for drugs and probes / Proc Natl Acad Sci U S A 109:11178~11183
Moore RA / 2011 / Single dose oral analgesics for acute postoperative pain in adults / Cochrane Database Syst Rev :CD008659
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