지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 278 - 284 (7page)
이용수
초록· 키워드
오류제보하기
Background: Establishment of laparoscopic cholecystectomy as an outpatient procedure has accentuated the clinical importance of reducing early postoperative pain, as well as postoperative nausea and vomiting (PONV). We therefore planned to evaluate the role of a multimodal approach in attenuating these problems.
Methods: One hundred and twenty adult patients of ASA physical status I and II and undergoing elective laparoscopic cholecystectomy were included in this prospective, randomized, placebo-controlled study. Patients were divided into four groups of 30 each to receive methylprednisolone 125 mg intravenously or etoricoxib 120 mg orally or a combination of methylprednisolone 125 mg intravenously and etoricoxib 120 mg orally or a placebo 1 hr prior to surgery. Patients were observed for postoperative pain, fentanyl consumption, PONV, fatigue and sedation, and respiratory depression. Results were analyzed by the ANOVA, a Chi square test, the Mann Whitney U test and by Fisher’s exact test. P values of less than 0.05 were considered to be significant.
Results: Postoperative pain and fentanyl consumption were significantly reduced by methylprednisolone, etoricoxib and their combination when compared with placebo (P＜0.05). The methylprednisolone + etoricoxib combination caused a significant reduction in postoperative pain and fentanyl consumption as compared to methylprednisolone or etoricoxib alone (P＜0.05); however, there was no significant difference between the methylprednisolone and etoricoxib groups (P＞0.05). The methylprednisolone and methylprednisolone + etoricoxib combination significantly reduced the incidence and severity of PONV and fatigue as well as the total number of patients requiring an antiemetic treatment compared to the placebo and etoricoxib (P＜0.05).
Conclusions: A preoperative single-dose administration of a combination of methylprednisolone and etoricoxib reduces postoperative pain along with fentanyl consumption, PONV, antiemetic requirements and fatigue more effectively than methylprednisolone or etoricoxib alone or a placebo.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Agarwal A / 2008 / Evaluation of a single preoperative dose of pregabalin for attenuation of postoperative pain after laparoscopic cholecystectomy / Br J Anaesth 101 : 700 ~
Bisgaard T / 2003 / Preoperative dexamethasone improves surgical outcome after laparoscopic cholecystectomy : a randomized double-blind placebocontrolled trial / Ann Surg 238
Bisgaard T / 2006 / Analgesic treatment after laparoscopic cholecystectomy:a critical assessment of the evidence / Anesthesiology 104 : 835 ~ 846
Chung F / 1999 / Factors contributing to a prolonged stay after ambulatory surgery / Anesth Analg 89 : 1352 ~ 1359
Clarke R / 2009 / Single dose oral etoricoxib for acute postoperative pain in adults / Cochrane Database Syst Rev (2) : CD004309 ~
Bisgaard T / 2003 / Preoperative dexamethasone improves surgical outcome after laparoscopic cholecystectomy : a randomized double-blind placebocontrolled trial / Ann Surg 238
Bisgaard T / 2006 / Analgesic treatment after laparoscopic cholecystectomy:a critical assessment of the evidence / Anesthesiology 104 : 835 ~ 846
Chung F / 1999 / Factors contributing to a prolonged stay after ambulatory surgery / Anesth Analg 89 : 1352 ~ 1359
Clarke R / 2009 / Single dose oral etoricoxib for acute postoperative pain in adults / Cochrane Database Syst Rev (2) : CD004309 ~
이 논문의 저자 정보
최근 본 자료
댓글(0)
0