지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 336 - 346 (11page)
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초록· 키워드
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Intrathecal drug delivery is an effective and safe option for the treatment of chronic pathology refractory to conventional pain therapies. Typical intrathecal administered drugs are opioids, baclofen, local anesthetics and adjuvant medications. Although knowledge about mechanisms of action of intrathecal drugs are every day more clear many doubt remain respect the correct location of intrathecal catheter in order to achieve the best therapeutic result. We analyze the factors that can affect drug distribution within the cerebrospinal fluid. Three categories of variables were identified: drug features, cerebrospinal fluid (CSF) dynamics and patients features. First category includes physicochemical properties and pharmacological features of intrathecal administered drugs with special attention to drug lipophilicity. In the second category, the variables in CSF flow, are considered that can modify the drug distribution within the CSF with special attention to the new theories of liquoral circulation. Last category try to explain inter-individual difference in baclofen response with difference that are specific for each patients such as the anatomical area to treat, patient posture or reaction to inflammatory stimulus. We conclude that a comprehensive evaluation of the patients, including imaging techniques to study the anatomy and physiology of intrathecal environment and CSF dynamics, could become essential in the future to the purpose of optimize the clinical outcome of intrathecal therapy.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Albright AL / 2007 / Cerebrospinal fluid baclofen concentrations in patients undergoing continuous intrathecal baclofen therapy / Dev Med Child Neurol 49 : 423 ~ 425
Avellino AM / 2000 / Intrathecal baclofen for the treatment of intractable spasticity of spine or brain etiology / Neuromodulation 3 : 75 ~ 81
Bernards CM / 2004 / Recent insights into the pharmacokinetics of spinal opioids and the relevance to opioid selection / Curr Opin Anaesthesiol 17 : 441 ~ 447
Burns AS / 2001 / Intrathecal baclofen in tetraplegia of spinal origin: efficacy for upper extremity hypertonia / Spinal Cord 39 : 413 ~ 419
Dario A / 2004 / A benefit-risk assessment of baclofen in severe spinal spasticity / Drug Saf 27 : 799 ~ 818
Avellino AM / 2000 / Intrathecal baclofen for the treatment of intractable spasticity of spine or brain etiology / Neuromodulation 3 : 75 ~ 81
Bernards CM / 2004 / Recent insights into the pharmacokinetics of spinal opioids and the relevance to opioid selection / Curr Opin Anaesthesiol 17 : 441 ~ 447
Burns AS / 2001 / Intrathecal baclofen in tetraplegia of spinal origin: efficacy for upper extremity hypertonia / Spinal Cord 39 : 413 ~ 419
Dario A / 2004 / A benefit-risk assessment of baclofen in severe spinal spasticity / Drug Saf 27 : 799 ~ 818
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