지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 203 - 209 (7page)
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초록· 키워드
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Background: Ketorolac has been used as a postoperative analgesia in combination with opioids. However, the use of ketorolac may produce serious side effects in vulnerable patients. Propacetamol is known to induce fewer side effects than ketorolac because it mainly affects the central nervous system. We compared the analgesic effects and patient satisfaction levels of each drug when combined with fentanyl patient-controlled analgesia (PCA).Methods: The patients were divided into two groups, each with n = 46. The patients in each group were given 60 mg of ketorolac or 2 g of propacetamol (mixed with fentanyl) for 10 minutes. The patients were then given 180 mg of ketorolac or 8 g of propacetamol (mixed with fentanyl and ramosetron) through PCA. We assessed the visual analogue pain scale (VAS) at the time point immediately before administration (baseline) and at 15, 30, and 60 minutes, and 24 hours after administration. Also, the side effects of each regimen and each patient’s degree of satisfaction were assessed.Results: There was a significant decline in the VAS score in both groups (P ＜ 0.05). However, there were no significant differences in the VAS scores between the groups at each time point. Satisfaction scores between the groups showed no significant difference.Conclusions: The efficacy of propacetamol is comparable to that of ketorolac in postoperative PCA with fentanyl. (Korean J Pain 2015; 28: 203-209)
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Bannwarth B / 1992 / Plasma and cerebrospinal fluid concentrations of paracetamol after a single intravenous dose of propacetamol / Br J Clin Pharmacol 34 : 79 ~ 81
Bjorkman R / 1994 / Acetaminophen blocks spinal hyperalgesia induced by NMDA and substance P / Pain 57 : 259 ~ 264
Bonnefont J / 2003 / Antinociceptive mechanism of action of paracetamol / Drugs 63 (2) : 1 ~ 4
Cashman J / 1995 / Nonsteroidal anti-inflammatory drugs in perisurgical pain management. Mechanisms of action and rationale for optimum use. / Drugs 49 : 51 ~ 70
Dahl JB / 1991 / Non-steroidal anti-inflammatory drugs : rationale for use in severe postoperative pain / Br J Anaesth 66 : 703 ~ 712
Bjorkman R / 1994 / Acetaminophen blocks spinal hyperalgesia induced by NMDA and substance P / Pain 57 : 259 ~ 264
Bonnefont J / 2003 / Antinociceptive mechanism of action of paracetamol / Drugs 63 (2) : 1 ~ 4
Cashman J / 1995 / Nonsteroidal anti-inflammatory drugs in perisurgical pain management. Mechanisms of action and rationale for optimum use. / Drugs 49 : 51 ~ 70
Dahl JB / 1991 / Non-steroidal anti-inflammatory drugs : rationale for use in severe postoperative pain / Br J Anaesth 66 : 703 ~ 712
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