지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 94 - 98 (5page)
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초록· 키워드
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Background:An intravenous infusion of lidocaine has been used on numerous occasions to produce analgesia in neuropathic pain. In the cases of failed back surgery syndrom, the pain generated as result of abnormal impulse from the dorsal root ganglion and spinal cord, for instance as a result of nerve injury may be particularly sensitive to lidocaine. The aim of the present study was to identify the effects of IV lidocaine on neuropathic pain items of FBSS.
Methods:The study was a randomized, prospective, double-blinded, crossover study involving eighteen patients with failed back surgery syndrome. The treatments were: 0.9% normal saline, lidocaine 1 mg/kg in 500 ml normal saline, and lidocaine 5 mg/kg in 500 ml normal saline over 60 minutes. The patients underwent infusions on three different appointments, at least two weeks apart. Thus all patients received all 3 treatments. Pain measurement was taken by visual analogue scale (VAS), and neuropathic pain questionnaire.
Results:Both lidocaine (1 mg/kg, 5 mg/kg) and placebo significantly reduced the intense, sharp, hot, dull, cold, sensitivity, itchy, unpleasant, deep and superficial of pain. The amount of change was not significantly different among either of the lidocaine and placebo, or among the lidocaine treatments themselves, for any of the pain responses, except sharp, dull, cold, unpleasant, and deep pain. And VAS was decreased during infusion in all 3 group and there were no difference among groups.
Conclusions:This study shows that 1 mg/kg, or 5 mg/kg of IV lidocaine, and palcebo was effective in patients with neuropathic pain attributable to FBSS, but effect of licoaine did not differ from placebo saline.
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참고문헌 (18)
참고문헌 신청
Attal N / 2000 / Intravenous lidocaine in central pain: a double-blind, placebo-controlled, psychophysical study / Neurology 54 : 564 ~ 574
Baranowski AP / 1999 / A trial of intravenous lidocaine on the pain and allodynia of postherpetic neuralgia / J Pain Symptom Manage 17 : 429 ~ 433
Burton CV / 1981 / Causes of failure of surgery on the lumbar spine / Clin Orthop Relat Res 157 : 191 ~ 199
Carroll IR / 2010 / Pain quality predicts lidocaine analgesia among patients with suspected neuropathic pain / Pain Med 11 : 617 ~ 621
Chabal C / 1989 / The effect of intravenous lidocaine, tocainide, and mexiletine on spontaneously active fibers originating in rat sciatic neuromas / Pain 38 : 333 ~ 338
Baranowski AP / 1999 / A trial of intravenous lidocaine on the pain and allodynia of postherpetic neuralgia / J Pain Symptom Manage 17 : 429 ~ 433
Burton CV / 1981 / Causes of failure of surgery on the lumbar spine / Clin Orthop Relat Res 157 : 191 ~ 199
Carroll IR / 2010 / Pain quality predicts lidocaine analgesia among patients with suspected neuropathic pain / Pain Med 11 : 617 ~ 621
Chabal C / 1989 / The effect of intravenous lidocaine, tocainide, and mexiletine on spontaneously active fibers originating in rat sciatic neuromas / Pain 38 : 333 ~ 338
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