지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 103 - 111 (9page)
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초록· 키워드
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Nefopam (NFP) is a non-opioid, non-steroidal, centrally acting analgesic drug that is derivative of the non- sedative benzoxazocine, developed and known in 1960s as fenazocine. Although the mechanisms of analgesic action of NFP are not well understood, they are similar to those of triple neurotransmitter (serotonin, norepinephrine, and dopamine) reuptake inhibitors and anticonvulsants. It has been used mainly as an analgesic drug for nociceptive pain, as well as a treatment for the prevention of postoperative shivering and hiccups. Based on NFP’s mechanisms of analgesic action, it is more suitable for the treatment of neuropathic pain. Intravenous administration of NFP should be given in single doses of 20 mg slowly over 15−20 min or with continuous infusion of 60−120 mg/d to minimize adverse effects, such as nausea, cold sweating, dizziness, tachycardia, or drowsiness. The usual dose of oral administration is three to six times per day totaling 90−180 mg. The ceiling effect of its analgesia is uncertain depending on the mechanism of pain relief. In conclusion, the recently discovered dual analgesic mechanisms of action, namely, a) descending pain modulation by triple neurotransmitter reuptake inhibition similar to antidepressants, and b) inhibition of long-term potentiation mediated by NMDA from the inhibition of calcium influx like gabapentinoid anticonvulsants or blockade of voltage-sensitive sodium channels like carbamazepine, enable NFP to be used as a therapeutic agent to treat neuropathic pain.
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참고문헌 (27)
참고문헌 신청
Alfonsi P / 2004 / Nefopam, a nonsedative benzoxazocine analgesic, selectively reduces the shivering threshold in unanesthetized subjects / Anesthesiology 100 : 37 ~ 43
Barrot M / 2012 / Tests and models of nociception and pain in rodents / Neuroscience 211 : 39 ~ 50
Bassett JR / 1969 / Studies on the peripheral pharmacology of fenazoxine, a potential antidepressant drug / Br J Pharmacol 37 : 69 ~ 78
Bilotta F / 2000 / Nefopam for severe hiccups / N Engl J Med 343 : 1973 ~ 1974
Bilotta F / 2001 / Nefopam for refractory postoperative hiccups / Anesth Analg 93 : 1358 ~ 1360
Barrot M / 2012 / Tests and models of nociception and pain in rodents / Neuroscience 211 : 39 ~ 50
Bassett JR / 1969 / Studies on the peripheral pharmacology of fenazoxine, a potential antidepressant drug / Br J Pharmacol 37 : 69 ~ 78
Bilotta F / 2000 / Nefopam for severe hiccups / N Engl J Med 343 : 1973 ~ 1974
Bilotta F / 2001 / Nefopam for refractory postoperative hiccups / Anesth Analg 93 : 1358 ~ 1360
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