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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 221 - 227 (7page)
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초록· 키워드
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Background:It has been reported that curcumin, the main active compound of Curcuma longa, also known as turmeric, exhibits antinociceptive properties. The aim of this study was to examine the participation of ATP-sensitive potassium channels (KATP channels) and, in particular, that of the L-arginine-nitric oxide-cyclic GMP-KATP channel pathway, in the antinociceptive effect of curcumin.
Methods:Pain was induced by the intraplantar injection of 1% formalin in the right hind paw of Wistar rats. Formalin-induced flinching behavior was interpreted as an expression of nociception. The antinociceptive effect of oral curcumin was explored in the presence and absence of local pretreatment with L-NAME, an inhibitor of nitric oxide synthase, ODQ, an inhibitor of soluble guanylyl cyclase, and glibenclamide, a blocker of KATP channels.
Results:Oral curcumin produced a dose-dependent antinociceptive effect in the 1% formalin test. Curcumin-induced antinociception was not altered by local L-NAME or ODQ, but was significantly impaired by glibenclamide.
Conclusions:Our results confirm that curcumin is an effective antinociceptive agent. Curcumin-induced antinociception appears to involve the participation of KATP channels at the peripheral level, as local injection of glibenclamide prevented its effect. Activation of KATP channels, however, does not occur by activation of the L-arginine-nitric oxide-cGMP- KATP channel pathway.
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참고문헌 (38)
참고문헌 신청
Rivera-Espinoza Y / 2009 / Pharmacological actions of curcumin in liver diseases or damage / Liver Int 29:1457~1466
Basnet P / 2011 / Curcumin: an anti-inflammatory molecule from a curry spice on the path to cancer treatment / Molecules 16:4567~4598
Goel A / 2008 / Curcumin as "Curecumin": from kitchen to clinic / Biochem Pharmacol 75:787~809
Aggarwal BB / 2009 / Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets / Trends Pharmacol Sci 30:85~94
Chainani-Wu N / 2003 / Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa) / J Altern Complement Med 9:161~168
Basnet P / 2011 / Curcumin: an anti-inflammatory molecule from a curry spice on the path to cancer treatment / Molecules 16:4567~4598
Goel A / 2008 / Curcumin as "Curecumin": from kitchen to clinic / Biochem Pharmacol 75:787~809
Aggarwal BB / 2009 / Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets / Trends Pharmacol Sci 30:85~94
Chainani-Wu N / 2003 / Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa) / J Altern Complement Med 9:161~168
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