지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 1 - 6 (6page)
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Background: Curcumin has been reported to have anti-inflammatory, antioxidant, antiviral, antifungal, antitumor, and antinociceptive activity when administered systemically. We investigated the analgesic efficacy of intrathecal curcumin in a rat model of inflammatory pain.
Methods: Male Sprague Dawley rats were prepared for intrathecal catheterization. Pain was evoked by injection of formalin solution (5%, 50 ml) into the hind paw. Curcumin doses of 62.5, 125, 250, and 500 mg were delivered through an intrathecal catheter to examine the flinching responses. The ED50 values (half-maximal effective dose) with 95% confidence intervals of curcumin for both phases of the formalin test were calculated from the dose-response lines fitted by least-squares linear regression on a log scale.
Results: In rats with intrathecal administration of curcumin, the flinching responses were significantly decreased in both phases. The slope of the regression line was significantly different from zero only in phase 2, and the ED50 value (95% confidence interval) of curcumin was 511.4 mg (23.5−1126.5). There was no apparent abnormal behavior following the administration of curcumin.
Conclusions: Intrathecal administration of curcumin decreased inflammatory pain in rats, and further investigation to elucidate the precise mechanism of spinal action of curcumin is warranted.
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참고문헌 (23)
참고문헌 신청
Banerjee M / 2003 / Modulation of inflammatory mediators by ibuprofen and curcumin treatment during chronic inflammation in rat / Immunopharmacol Immunotoxicol 25 : 213 ~ 224
Chainani-Wu N / 2003 / Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa) / J Altern Complement Med 9 : 161 ~ 168
Coderre TJ / 2007 / The formalin test. In: Encyclopedia of pain / Springer : 795 ~ 799
Deshpande SS / 1998 / Subchronic oral toxicity of turmeric and ethanolic turmeric extract in female mice and rats / Toxicol Lett 95 : 183 ~ 193
Fairbanks CA / 2003 / Spinal delivery of analgesics in experimental models of pain and analgesia / Adv Drug Deliv Rev 55 : 1007 ~ 1041
Chainani-Wu N / 2003 / Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa) / J Altern Complement Med 9 : 161 ~ 168
Coderre TJ / 2007 / The formalin test. In: Encyclopedia of pain / Springer : 795 ~ 799
Deshpande SS / 1998 / Subchronic oral toxicity of turmeric and ethanolic turmeric extract in female mice and rats / Toxicol Lett 95 : 183 ~ 193
Fairbanks CA / 2003 / Spinal delivery of analgesics in experimental models of pain and analgesia / Adv Drug Deliv Rev 55 : 1007 ~ 1041
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