지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 86 - 95 (10page)
이용수
초록· 키워드
오류제보하기
Background: The present study was designed to examine the functional recovery following spinal cord injury (SCI) by adjusting the parameters of impact force and dwell-time using the Infinite Horizon (IH) impactor device. Methods: Sprague-Dawley rats (225−240 g) were divided into eight injury groups based on force of injury (Kdyn) and dwell time (seconds), indicated as Force-Dwell time: 150-4, 150-3, 150-2, 150-1, 150-0, 200-0, 90-2 and sham controls, respectively. Results: After T10 SCI, higher injury force produced greater spinal cord displacement (P ＜ 0.05) and showed a significant correlation (r = 0.813) between the displacement and the force (P ＜ 0.05). In neuropathic pain-like behavior, the percent of paw withdrawals scores in the hindpaw for the 150-4, 150-3, 150-2, 150-1 and the 200-0 injury groups were significantly lowered compared with sham controls (P ＜ 0.05). The recovery of locomotion had a significant within-subjects effect of time (P ＜ 0.05) and the 150-0 group had increased recovery compared to other groups (P ＜ 0.05). In addition, the 200-0 and the 90-2 recovered significantly better than all the 150 kdyn impact groups that included a dwell-time (P ＜ 0.05). In recovery of spontaneous bladder function, the 150-4 injury group took significantly longer recovery time whereas the 150-0 and the 90-2 groups had the shortest recovery times. Conclusions: The present study demonstrates SCI parameters optimize development of mechanical allodynia and other pathological outcomes. (Korean J Pain 2016; 29: 86-95)
목차
등록된 정보가 없습니다.
참고문헌 (39)
참고문헌 신청
Bruce JC / 2002 / Chronic pain after clip-compression injury of the rat spinal cord / Exp Neurol 178:33~48
Mills CD / 2001 / Changes in exploratory behavior as a measure of chronic central pain following spinal cord injury / J Neurotrauma 18:1091~1105
Vierck CJ Jr / 2000 / Allodynia and hyperalgesia within dermatomes caudal to a spinal cord injury in primates and rodents / Prog Brain Res 129:411~428
Lindsey AE / 2000 / An analysis of changes in sensory thresholds to mild tactile and cold stimuli after experimental spinal cord injury in the rat / Neurorehabil Neural Repair 14:287~300
Hulsebosch CE / 2000 / Rodent model of chronic central pain after spinal cord contusion injury and effects of gabapentin / J Neurotrauma 17:1205~1217
Mills CD / 2001 / Changes in exploratory behavior as a measure of chronic central pain following spinal cord injury / J Neurotrauma 18:1091~1105
Vierck CJ Jr / 2000 / Allodynia and hyperalgesia within dermatomes caudal to a spinal cord injury in primates and rodents / Prog Brain Res 129:411~428
Lindsey AE / 2000 / An analysis of changes in sensory thresholds to mild tactile and cold stimuli after experimental spinal cord injury in the rat / Neurorehabil Neural Repair 14:287~300
Hulsebosch CE / 2000 / Rodent model of chronic central pain after spinal cord contusion injury and effects of gabapentin / J Neurotrauma 17:1205~1217
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