지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 183 - 189 (7page)
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초록· 키워드
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Background: The aim of this study was to evaluate the correlation between sensitization to mite and airway hyperresponsiveness in mite-sensitive young adults with asthma.
Methods: This study included 72 young male Korean conscripts aged between 19 and 30 years who complained of recurrent wheezing and dyspnea with nocturnal aggravation and no history of other lung disease, asthma exacerbation, or treatment against asthma except short-acting beta2 agonists over the last 2 months. They underwent pulmonary function tests and methacholine challenge tests. In 63 subjects, the forced expiratory volume in 1 second was more than 60% of the predicted value, and the provocative concentration of methacholine causing a 20% decline in forced expiratory volume in 1 second in methacholine challenge tests was less than 16 mg/mL. Serum was collected from these subjects to measure specific immunoglobulin E against Dermatophagoides farinae and Dermatophagoides pteronyssinus using the AdvanSure Allergy Screen test.
Results: Specific immunoglobulin E against Dermatophagoides farinae and Dermatophagoides pteronyssinus correlated negatively with provocative concentration of methacholine causing a 20% decline in forced expiratory volume in 1 second in 50 subjects who were mite-sensitive (γ=−0.368, P=0.009; and γ=−0.415, P=0.003, respectively). However, specific immunoglobulin E against Dermatophagoides farinae and Dermatophagoides pteronyssinus was not correlated with forced vital capacity, forced expiratory volume in 1 second, or forced expiratory volume in 1 second/forced vital capacity. Conclusion: Sensitization to mites may correlated with airway hyperresponsiveness in mite-sensitive young adults with asthma.
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참고문헌 (21)
참고문헌 신청
Cline MG / 1994 / Determinants of percent predicted FEV1 in current asthmatic subjects / Chest 106 : 1089 ~ 1093
Clough JB / 1991 / Effect of atopy on the natural history of symptoms, peak expiratory flow, and bronchial responsiveness in 7- and 8-year-old children with cough and wheeze
Crapo RO / 2000 / Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of D
Custovic A / 1996 / Exposure to house dust mite allergens and the clinical activity of asthma / J Allergy Clin Immunol 98 : 64 ~ 72
Ehnert B / 1992 / Reducing domestic exposure to dust mite allergen reduces bronchial hyperreactivity in sensitive children with asthma / J Allergy Clin Immunol 90 : 135 ~ 138
Clough JB / 1991 / Effect of atopy on the natural history of symptoms, peak expiratory flow, and bronchial responsiveness in 7- and 8-year-old children with cough and wheeze
Crapo RO / 2000 / Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of D
Custovic A / 1996 / Exposure to house dust mite allergens and the clinical activity of asthma / J Allergy Clin Immunol 98 : 64 ~ 72
Ehnert B / 1992 / Reducing domestic exposure to dust mite allergen reduces bronchial hyperreactivity in sensitive children with asthma / J Allergy Clin Immunol 90 : 135 ~ 138
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