지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 115 - 121 (7page)
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초록· 키워드
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Background: The biochemical properties of green tea extracts can generally be divided into 4 aspects: antioxidative, anticarcinogenic, anti-inflammatory and antiradiation activities. Green tea extracts have 20-fold more antioxidative activity than vitamin C and also have a wide range of anti-inflammatory activity. Therefore, it is presumed that it would play a role in the treatment of chronic inflammatory disorders. Pathophysiology of immunologic disorders involves overexpression of proinflammatory mediators, including nitric oxide (NO) and prostaglandin E2 (PGE2). Methods: After the treatment of different concentrations for Green Tea Cell Water in lipopolysaccharide (LPS)-treated Raw 264.7 cells, the levels of NO and PGE2 were measured in the media. Furthermore, we analyzed the expression levels of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), and phosphorylation of inhibitory kappa Bα using western blot. Results: Green Tea Cell Water suppressed the LPS-induced expression of iNOS and COX-2 in a concentration-dependent manner. Phosphorylation of the inhibitory-κB was also inhibited. Conclusion: Our results suggest that Green Tea Cell Water may be a significant inflammatory factor and can be used a therapeutic modality in managing chronic inflammatory diseases.
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참고문헌 (26)
참고문헌 신청
Funk CD / 1991 / Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment / FASEB J 5 : 2304 ~ 2312
Hara Y / 1987 / Angiotensin 1 converting enzyme inhibiting activity of tea component / Nippon Nogeikagaku Kaishi 61 : 803 ~ 808
Hayatsu H / 1992 / Suppression of genotoxicity of carcinogens by (-)-epigallocatechin gallate / Prev Med 21 : 370 ~ 376
Hippeli S / 1999 / Inhibition of biochemical model reactions for inflammatory processes by plant extracts: a review on recent developments / Free Radic Res 31 : S81 ~ S87
Hiramoto K / 1996 / Effect of plant phenolics on the formation of the spin-adduct of hydroxyl radical and the DNA strand breaking by hydroxyl radical / Biol Pharm Bull 19 :
Hara Y / 1987 / Angiotensin 1 converting enzyme inhibiting activity of tea component / Nippon Nogeikagaku Kaishi 61 : 803 ~ 808
Hayatsu H / 1992 / Suppression of genotoxicity of carcinogens by (-)-epigallocatechin gallate / Prev Med 21 : 370 ~ 376
Hippeli S / 1999 / Inhibition of biochemical model reactions for inflammatory processes by plant extracts: a review on recent developments / Free Radic Res 31 : S81 ~ S87
Hiramoto K / 1996 / Effect of plant phenolics on the formation of the spin-adduct of hydroxyl radical and the DNA strand breaking by hydroxyl radical / Biol Pharm Bull 19 :
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